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Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Ann+Hematol 2020 ; 99 (9): 1967-1977 Nephropedia Template TP
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Thalassemia in the emergency department: special considerations for a rare disease #MMPMID32621178
Saliba AN; Atoui A; Labban M; Hamade H; Bou-Fakhredin R; Mufarrij A; Taher AT
Ann Hematol 2020[Sep]; 99 (9): 1967-1977 PMID32621178show ga
Thalassemia is characterized by a defect in the synthesis of one or more of the globin subunits of hemoglobin. This defect results in imbalance in the alpha/beta-globin chain ratio, ineffective erythropoiesis, chronic hemolytic anemia, and iron overload. With advances in diagnosis, treatment, and transfusion support, the prognosis of patients with thalassemia has improved over the past few decades. An increasing number of patients with thalassemia is living with long-term complications, including cardiomyopathy, chronic liver disease, endocrinopathy, and infections. In this paper, we review common complications that bring the patient with thalassemia to urgent or emergent medical attention. We also discuss the aspects of emergency care that are most relevant while caring for the patient with thalassemia in the emergency department.