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10.1038/s41379-020-0613-1 http://scihub22266oqcxt.onion/10.1038/s41379-020-0613-1 32620916!7333227!32620916     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Mod+Pathol 2020 ; 33 (11): 2139-2146 Nephropedia Template TP {{tp|p=32620916|t=2020. Histiocytic hyperplasia with hemophagocytosis and acute alveolar damage in COVID-19 infection |pdf=|usr=}}{{32620916}} gab.com Text Histiocytic hyperplasia with hemophagocytosis and acute alveolar damage in COVID-19 infection JO: Mod Pathol http://www.kidney.de/pget.php?&tw=1&pmid=32620916 #FOAvip The spectrum of COVID-19 infection includes acute respiratory distress syndrome (ARDS) and macrophage activation syndrome (MAS), although the histological basis for these disorders has not been thoroughly explored. Post-mortem pulmonary and bone marrow biopsies were performed in 33 patients. Samples were studied with a combination of morphological and immunohistochemical techniques. Bone marrow studies were also performed in three living patients. Bone marrow post-mortem studies showed striking lesions of histiocytic hyperplasia with hemophagocytosis (HHH) in most (16/17) cases. This was also observed in three alive patients, where it mimicked the changes observed in hemophagocytic histiocytosis. Pulmonary changes included a combination of diffuse alveolar damage with fibrinous microthrombi predominantly involving small vessels, in particular the alveolar capillary. These findings were associated with the analytical and clinical symptoms, which helps us understand the respiratory insufficiency and reveal the histological substrate for the macrophage activation syndrome-like exhibited by these patients. Our results confirm that COVID-19 infection triggers a systemic immune-inflammatory disease and allow specific therapies to be proposed. Twit Text FOAVip Histiocytic hyperplasia with hemophagocytosis and acute alveolar damage in COVID-19 infection ????Mod Pathol http://www.kidney.de/pget.php?&tw=1&pmid=32620916 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32620916 #FOAvip English Wikipedia <ref>{{Cite pmid|32620916}}</ref> Histiocytic hyperplasia with hemophagocytosis and acute alveolar damage in COVID-19 infection #MMPMID32620916 Prieto-Perez L; Fortes J; Soto C; Vidal-Gonzalez A; Alonso-Riano M; Lafarga M; Cortti MJ; Lazaro-Garcia A; Perez-Tanoira R; Trascasa A; Antonio A; Cordoba R; Rodriguez-Pinilla SM; Cedeno O; Peces-Barba G; Fernandez-Ormaechea I; Diez Medrano MJ; Lopez de Las Heras M; Cabello A; Petkova E; Alvarez B; Carrillo I; Silva AM; Castellanos M; Calpena S; Valverde-Monge M; Fresneda D; Rubio-Martin R; Cornejo I; Astilleros Blanco de Cordova L; de la Fuente S; Recuero S; Gorgolas M; Piris MA Mod Pathol 2020[Nov]; 33 (11): 2139-2146 PMID32620916show ga The spectrum of COVID-19 infection includes acute respiratory distress syndrome (ARDS) and macrophage activation syndrome (MAS), although the histological basis for these disorders has not been thoroughly explored. Post-mortem pulmonary and bone marrow biopsies were performed in 33 patients. Samples were studied with a combination of morphological and immunohistochemical techniques. Bone marrow studies were also performed in three living patients. Bone marrow post-mortem studies showed striking lesions of histiocytic hyperplasia with hemophagocytosis (HHH) in most (16/17) cases. This was also observed in three alive patients, where it mimicked the changes observed in hemophagocytic histiocytosis. Pulmonary changes included a combination of diffuse alveolar damage with fibrinous microthrombi predominantly involving small vessels, in particular the alveolar capillary. These findings were associated with the analytical and clinical symptoms, which helps us understand the respiratory insufficiency and reveal the histological substrate for the macrophage activation syndrome-like exhibited by these patients. Our results confirm that COVID-19 infection triggers a systemic immune-inflammatory disease and allow specific therapies to be proposed. |Aged[MESH] |Aged, 80 and over[MESH] |Betacoronavirus[MESH] |Bone Marrow/pathology[MESH] |COVID-19[MESH] |Coronavirus Infections/*pathology[MESH] |Female[MESH] |Histiocytes/*pathology[MESH] |Humans[MESH] |Hyperplasia/pathology/virology[MESH] |Lung/pathology[MESH] |Lymphohistiocytosis, Hemophagocytic/*pathology/*virology[MESH] |Male[MESH] |Middle Aged[MESH] |Pandemics[MESH] |Pneumonia, Viral/*pathology[MESH] |Respiratory Distress Syndrome/*pathology/*virology[MESH]Histiocytic hyperplasia with hemophagocytosis and acute alveolar damag(epmc).pdf DeepDyve Pubget Overpricing