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10.1016/j.ejca.2020.06.017

http://scihub22266oqcxt.onion/10.1016/j.ejca.2020.06.017
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32619884!7315961!32619884
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suck abstract from ncbi


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pmid32619884      Eur+J+Cancer 2020 ; 136 (ä): 4-6
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  • Could anti-CD20 therapy jeopardise the efficacy of a SARS-CoV-2 vaccine? #MMPMID32619884
  • Houot R; Levy R; Cartron G; Armand P
  • Eur J Cancer 2020[Sep]; 136 (ä): 4-6 PMID32619884show ga
  • A vaccine against SARS-CoV-2 might represent the most promising approach to halt durably the current COVID-19 pandemic. We believe that anti-CD20 therapy may jeopardise the efficacy of such a vaccine. This is regrettable because patients receiving anti-CD20 therapy (i.e. those with haematologic malignancies or autoimmune disorders) are particularly at risk of severe COVID-19 and, as such, are the most in need of a vaccine. Here, we review the reasons why anti-CD20 therapy may abrogate or diminish the efficacy of a vaccine against SARS-CoV-2 and we draw physicians' attention towards this potential risk so that it can be considered when evaluating the risk/benefit ratio of anti-CD20 therapy during the current pandemic.
  • |*Antigens, CD20[MESH]
  • |Antibodies, Monoclonal, Humanized/adverse effects[MESH]
  • |Betacoronavirus[MESH]
  • |COVID-19[MESH]
  • |COVID-19 Vaccines[MESH]
  • |Coronavirus Infections/*prevention & control[MESH]
  • |Drug Interactions[MESH]
  • |Humans[MESH]
  • |Immunologic Factors/*adverse effects[MESH]
  • |Pandemics/*prevention & control[MESH]
  • |Pneumonia, Viral/*prevention & control[MESH]
  • |Rituximab/*adverse effects[MESH]
  • |SARS-CoV-2[MESH]
  • |Treatment Outcome[MESH]


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