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10.1016/j.ijid.2020.06.093

http://scihub22266oqcxt.onion/10.1016/j.ijid.2020.06.093
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32619764!7326458!32619764
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suck abstract from ncbi


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pmid32619764      Int+J+Infect+Dis 2020 ; 98 (ä): 290-293
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  • Case report study of the first five COVID-19 patients treated with remdesivir in France #MMPMID32619764
  • Dubert M; Visseaux B; Isernia V; Bouadma L; Deconinck L; Patrier J; Wicky PH; Le Pluart D; Kramer L; Rioux C; Le Hingrat Q; Houhou-Fidouh N; Yazdanpanah Y; Ghosn J; Lescure FX
  • Int J Infect Dis 2020[Sep]; 98 (ä): 290-293 PMID32619764show ga
  • Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been identified as the virus responsible for the coronavirus disease 2019 (COVID-19) outbreak worldwide. Data on treatment are scare and parallels have been made between SARS-CoV-2 and other coronaviruses. Remdesivir is a broad-spectrum antiviral with efficient in vitro activity against SARS-CoV-2. Evidence of clinical improvement in patients with severe COVID-19 treated with remdesivir is controversial. The aim of this study was to describe the clinical outcomes and virological monitoring of the first five COVID-19 patients admitted to the intensive care unit of Bichat-Claude Bernard University Hospital, Paris, France, for severe pneumonia related to SARS-CoV-2 and treated with remdesivir. Quantitative reverse transcription PCR was used to monitor SARS-CoV-2 in blood plasma and the lower and upper respiratory tract. Among the five patients treated, two needed mechanical ventilation and one needed high-flow cannula oxygen. A significant decrease in SARS-CoV-2 viral load in the upper respiratory tract was observed in most cases, but two patients died with active SARS-CoV-2 replication in the lower respiratory tract. Plasma samples were positive for SARS-CoV-2 in only one patient. Remdesivir was interrupted before the initialy planned duration in four patients, two because of alanine aminotransferase elevations (3 to 5 normal range) and two because of renal failure requiring renal replacement. This case series of five COVID-19 patients requiring intensive care unit treatment for respiratory distress and treated with remdesivir, highlights the complexity of remdesivir use in such critically ill patients.
  • |Adenosine Monophosphate/adverse effects/*analogs & derivatives/therapeutic use[MESH]
  • |Adult[MESH]
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |Alanine/adverse effects/*analogs & derivatives/therapeutic use[MESH]
  • |Antiviral Agents/adverse effects/therapeutic use[MESH]
  • |Betacoronavirus/drug effects/physiology[MESH]
  • |COVID-19[MESH]
  • |Coronavirus Infections/*drug therapy/virology[MESH]
  • |Female[MESH]
  • |France[MESH]
  • |Hospitalization[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*drug therapy/virology[MESH]
  • |SARS-CoV-2[MESH]
  • |Viral Load/drug effects[MESH]


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