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10.1097/AOG.0000000000004050

http://scihub22266oqcxt.onion/10.1097/AOG.0000000000004050
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32618794!ä!32618794

suck abstract from ncbi


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pmid32618794      Obstet+Gynecol 2020 ; 136 (5): 1025-1029
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  • Tocilizumab and Remdesivir in a Pregnant Patient With Coronavirus Disease 2019 (COVID-19) #MMPMID32618794
  • Naqvi M; Zakowski P; Glucksman L; Smithson S; Burwick RM
  • Obstet Gynecol 2020[Nov]; 136 (5): 1025-1029 PMID32618794show ga
  • BACKGROUND: There are limited data regarding treatment options for pregnant women with severe coronavirus disease 2019 (COVID-19). CASE: A 35-year-old primigravid patient at 22 weeks of gestation presented with 7 days of fever, cough, anosmia, and dyspnea. Nasopharyngeal swab was positive for the novel coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and a chest X-ray demonstrated bilateral patchy infiltrates. Laboratory evaluation was notable for marked elevation of interleukin-6 and C-reactive protein concentrations. On hospital day 3, owing to increased dyspnea and oxygen requirement, the patient was treated with tocilizumab followed by 5 days of remdesivir. She responded well, recovered to room air, and was discharged home after a 9-day hospitalization. CONCLUSION: Tocilizumab and remdesivir may be effective for treatment of severe COVID-19 in pregnancy, but additional data are needed to guide risk-benefit considerations.
  • |*Coronavirus Infections/blood/diagnosis/drug therapy/physiopathology[MESH]
  • |*Pandemics[MESH]
  • |*Pneumonia, Viral/blood/diagnosis/drug therapy/etiology/physiopathology[MESH]
  • |*Pregnancy Complications, Infectious/blood/diagnosis/drug therapy[MESH]
  • |Adenosine Monophosphate/administration & dosage/*analogs & derivatives[MESH]
  • |Adult[MESH]
  • |Alanine/administration & dosage/*analogs & derivatives[MESH]
  • |Antibodies, Monoclonal, Humanized/*administration & dosage[MESH]
  • |Antiviral Agents/administration & dosage[MESH]
  • |Betacoronavirus/isolation & purification[MESH]
  • |C-Reactive Protein/analysis[MESH]
  • |COVID-19[MESH]
  • |COVID-19 Drug Treatment[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Interleukin-6/blood[MESH]
  • |Lung/*diagnostic imaging[MESH]
  • |Oximetry/methods[MESH]
  • |Pregnancy[MESH]
  • |Radiography, Thoracic/methods[MESH]
  • |SARS-CoV-2[MESH]


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