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10.1002/jmv.26254 http://scihub22266oqcxt.onion/10.1002/jmv.26254 32617987!7361355!32617987     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32617987&cmd=llinks): Failed to open stream: HTTP request failed! 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Microstructure, pathophysiology, and potential therapeutics of COVID-19: A comprehensive review |pdf=|usr=}}{{32617987}} gab.com Text Microstructure, pathophysiology, and potential therapeutics of COVID-19: A comprehensive review JO: J Med Virol http://www.kidney.de/pget.php?&tw=1&pmid=32617987 #FOAvip There have been over seven million cases and almost 413 372 deaths globally due to the novel coronavirus (2019-nCoV) associated disease COVID-19, as of 11 June 2020. Phylogenetic analysis suggests that there is a common source for these infections. The overall sequence similarities between the spike protein of 2019-nCoV and that of SARS-CoV are known to be around 76% to 78% and 73% to 76% for the whole protein and receptor-binding domain (RBD), respectively. Thus, they have the potential to serve as the drug and/or vaccine candidate. However, the individual response against 2019-nCoV differs due to genetic variations in the human population. Understanding the variations in angiotensin-converting enzyme 2 (ACE2) and human leukocyte antigen (HLA) that may affect the severity of 2019-nCoV infection could help in identifying individuals at a higher risk from the COVID-19. A number of potential drugs/vaccines as well as antibody/cytokine-based therapeutics are in various developmental stages of preclinical/clinical trials against SARS-CoV, MERS-CoV, and 2019-nCoV with substantial cross-reactivity, and may be used against COVID-19. For diagnosis, the reverse-transcription polymerase chain reaction is the gold standard test for initial diagnosis of COVID-19. A kit based on serological tests are also recommended for investigating the spread of COVID-19 but this is challenging due to the antibodies cross-reactivity. This review comprehensively summarizes the recent reports available regarding the host-pathogen interaction, morphological and genomic structure of the virus, and the diagnostic techniques as well as the available potential therapeutics against COVID-19. Twit Text FOAVip Microstructure, pathophysiology, and potential therapeutics of COVID-19: A comprehensive review ????J Med Virol http://www.kidney.de/pget.php?&tw=1&pmid=32617987 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32617987 #FOAvip English Wikipedia <ref>{{Cite pmid|32617987}}</ref> Microstructure, pathophysiology, and potential therapeutics of COVID-19: A comprehensive review #MMPMID32617987 Singh SP; Pritam M; Pandey B; Yadav TP J Med Virol 2021[Jan]; 93 (1): 275-299 PMID32617987show ga There have been over seven million cases and almost 413 372 deaths globally due to the novel coronavirus (2019-nCoV) associated disease COVID-19, as of 11 June 2020. Phylogenetic analysis suggests that there is a common source for these infections. The overall sequence similarities between the spike protein of 2019-nCoV and that of SARS-CoV are known to be around 76% to 78% and 73% to 76% for the whole protein and receptor-binding domain (RBD), respectively. Thus, they have the potential to serve as the drug and/or vaccine candidate. However, the individual response against 2019-nCoV differs due to genetic variations in the human population. Understanding the variations in angiotensin-converting enzyme 2 (ACE2) and human leukocyte antigen (HLA) that may affect the severity of 2019-nCoV infection could help in identifying individuals at a higher risk from the COVID-19. A number of potential drugs/vaccines as well as antibody/cytokine-based therapeutics are in various developmental stages of preclinical/clinical trials against SARS-CoV, MERS-CoV, and 2019-nCoV with substantial cross-reactivity, and may be used against COVID-19. For diagnosis, the reverse-transcription polymerase chain reaction is the gold standard test for initial diagnosis of COVID-19. A kit based on serological tests are also recommended for investigating the spread of COVID-19 but this is challenging due to the antibodies cross-reactivity. This review comprehensively summarizes the recent reports available regarding the host-pathogen interaction, morphological and genomic structure of the virus, and the diagnostic techniques as well as the available potential therapeutics against COVID-19. |*Host-Pathogen Interactions[MESH] |Animals[MESH] |Antibodies, Viral/immunology[MESH] |COVID-19/*diagnosis/*physiopathology/*therapy[MESH] |Chiroptera/virology[MESH] |Cross Reactions[MESH] |Humans[MESH] |Phylogeny[MESH] |Receptors, Virus/chemistry[MESH] |SARS-CoV-2/drug effects/*genetics[MESH]Microstructure, pathophysiology, and potential therapeutics of COVID-1(epmc).pdf DeepDyve Pubget Overpricing