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10.1007/s11239-020-02202-8

http://scihub22266oqcxt.onion/10.1007/s11239-020-02202-8
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32617807!7331913!32617807
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suck abstract from ncbi


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pmid32617807      J+Thromb+Thrombolysis 2020 ; 50 (3): 558-566
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  • Rate of venous thromboembolism in a prospective all-comers cohort with COVID-19 #MMPMID32617807
  • Rieder M; Goller I; Jeserich M; Baldus N; Pollmeier L; Wirth L; Supady A; Bode C; Busch HJ; Schmid B; Duerschmied D; Gauchel N; Lother A
  • J Thromb Thrombolysis 2020[Oct]; 50 (3): 558-566 PMID32617807show ga
  • COVID-19 is associated with a variety of clinical complications including coagulopathy, which frequently results in venous thromboembolism (VTE). Retrospective analyses reported a markedly increased rate of VTEs in COVID-19. However, most recent studies on coagulopathy in COVID-19 were only focused on critically ill patients, and without suitable control groups. We aimed to evaluate the rate of VTEs in an all-comers cohort with suspected COVID-19 during a 30-days follow-up period. We also studied the level of D-dimers and their association with the course of disease. In our prospective single-center study (DRKS00021206, 03/30/2020), we analyzed 190 patients with suspected COVID-19 admitted to the emergency department between March and April 2020. Forty-nine patients were SARS-CoV-2 positive (25.8%). The 141 SARS-CoV-2-negative patients served as control group. After completion of a 30-days follow-up, VTE was diagnosed in 3 patients of the SARS-CoV-2-positive group (6.1%, amongst these 2 ICU cases) versus 5 patients in the SARS-CoV-2-negative group (3.5%), however the difference was not statistically significant (p = 0.427). 30-days mortality was similar in both groups (6.1% vs. 5%, p = 0.720). Disease severity correlated with the maximum level of D-dimers during follow-up in COVID-19. The rate of VTE was numerically higher in SARS-CoV-2 positive all-comers presenting with suspected COVID-19 as compared to well-matched controls suffering from similar symptoms. VTEs in the COVID-19 group predominantly occurred in ICU courses. The maximum level of D-dimers during follow-up was associated with disease severity in COVID-19, whereas the level of D-dimers at admission was not.
  • |Adult[MESH]
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |Betacoronavirus/pathogenicity[MESH]
  • |Biomarkers/blood[MESH]
  • |COVID-19[MESH]
  • |Case-Control Studies[MESH]
  • |Coronavirus Infections/blood/diagnosis/*epidemiology/virology[MESH]
  • |Female[MESH]
  • |Fibrin Fibrinogen Degradation Products/metabolism[MESH]
  • |Germany/epidemiology[MESH]
  • |Host-Pathogen Interactions[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/blood/diagnosis/*epidemiology/virology[MESH]
  • |Prospective Studies[MESH]
  • |Pulmonary Embolism/blood/diagnosis/*epidemiology/virology[MESH]
  • |Registries[MESH]
  • |Risk Assessment[MESH]
  • |Risk Factors[MESH]
  • |SARS-CoV-2[MESH]
  • |Severity of Illness Index[MESH]
  • |Time Factors[MESH]
  • |Venous Thromboembolism/blood/diagnosis/*epidemiology/virology[MESH]


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