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10.1128/mBio.01175-20 http://scihub22266oqcxt.onion/10.1128/mBio.01175-20 32616514!7338079!32616514     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       mBio 2020 ; 11 (4): ä Nephropedia Template TP {{tp|p=32616514|t=2020. Pathogenesis of COVID-19 from the Perspective of the Damage-Response Framework |pdf=|usr=}}{{32616514}} gab.com Text Pathogenesis of COVID-19 from the Perspective of the Damage-Response Framework JO: mBio http://www.kidney.de/pget.php?&tw=1&pmid=32616514 #FOAvip The coronavirus disease 2019 (COVID-19) pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) presents the medical community with a significant challenge. COVID-19 is an entirely new disease with disparate clinical manifestations that are difficult to reconcile with a single pathogenic principle. Here, we explain how the flexible paradigm of the "damage-response framework" (DRF) of microbial pathogenesis can organize the varied manifestations of COVID-19 into a synthesis that accounts for differences in susceptibility of vulnerable populations as well as for differing manifestations of COVID-19 disease. By focusing on mechanisms of host damage, particularly immune-mediated damage, the DRF provides a lens to understand COVID-19 pathogenesis and to consider how potential therapies could alter the outcome of this disease. Twit Text FOAVip Pathogenesis of COVID-19 from the Perspective of the Damage-Response Framework ????mBio http://www.kidney.de/pget.php?&tw=1&pmid=32616514 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32616514 #FOAvip English Wikipedia <ref>{{Cite pmid|32616514}}</ref> Pathogenesis of COVID-19 from the Perspective of the Damage-Response Framework #MMPMID32616514 Pirofski LA; Casadevall A mBio 2020[Jul]; 11 (4): ä PMID32616514show ga The coronavirus disease 2019 (COVID-19) pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) presents the medical community with a significant challenge. COVID-19 is an entirely new disease with disparate clinical manifestations that are difficult to reconcile with a single pathogenic principle. Here, we explain how the flexible paradigm of the "damage-response framework" (DRF) of microbial pathogenesis can organize the varied manifestations of COVID-19 into a synthesis that accounts for differences in susceptibility of vulnerable populations as well as for differing manifestations of COVID-19 disease. By focusing on mechanisms of host damage, particularly immune-mediated damage, the DRF provides a lens to understand COVID-19 pathogenesis and to consider how potential therapies could alter the outcome of this disease. |Betacoronavirus/isolation & purification/pathogenicity[MESH] |COVID-19[MESH] |Coronavirus Infections/epidemiology/*pathology/therapy/*virology[MESH] |Humans[MESH] |Pandemics[MESH] |Pneumonia, Viral/epidemiology/*pathology/therapy/*virology[MESH]Pathogenesis of COVID-19 from the Perspective of the Damage-Response F(epmc).pdf DeepDyve Pubget Overpricing