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10.1016/j.meegid.2020.104438 http://scihub22266oqcxt.onion/10.1016/j.meegid.2020.104438 32615317!7832673!32615317     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Infect+Genet+Evol 2020 ; 85 (ä): 104438 Nephropedia Template TP {{tp|p=32615317|t=2020. Gene signatures of SARS-CoV/SARS-CoV-2-infected ferret lungs in short- and long-term models |pdf=|usr=}}{{32615317}} gab.com Text Gene signatures of SARS-CoV/SARS-CoV-2-infected ferret lungs in short- and long-term models JO: Infect Genet Evol http://www.kidney.de/pget.php?&tw=1&pmid=32615317 #FOAvip Coronaviruses (CoVs) consist of six strains, and the severe acute respiratory syndrome coronavirus (SARS-CoV), newly found coronavirus (SARS-CoV-2) has rapidly spread leading to a global outbreak. The ferret (Mustela putorius furo) serves as a useful animal model for studying SARS-CoV/SARS-CoV-2 infection and developing therapeutic strategies. A holistic approach for distinguishing differences in gene signatures during disease progression is lacking. The present study discovered gene expression profiles of short-term (3 days) and long-term (14 days) ferret models after SARS-CoV/SARS-CoV-2 infection using a bioinformatics approach. Through Gene Ontology (GO) and MetaCore analyses, we found that the development of stemness signaling was related to short-term SARS-CoV/SARS-CoV-2 infection. In contrast, pathways involving extracellular matrix and immune responses were associated with long-term SARS-CoV/SARS-CoV-2 infection. Some highly expressed genes in both short- and long-term models played a crucial role in the progression of SARS-CoV/SARS-CoV-2 infection, including DPP4, BMP2, NFIA, AXIN2, DAAM1, ZNF608, ME1, MGLL, LGR4, ABHD6, and ACADM. Meanwhile, we revealed that metabolic, glucocorticoid, and reactive oxygen species-associated networks were enriched in both short- and long-term infection models. The present study showed alterations in gene expressions from short-term to long-term SARS-CoV/SARS-CoV-2 infection. The current result provides an explanation of the pathophysiology for post-infectious sequelae and potential targets for treatment. Twit Text FOAVip Gene signatures of SARS-CoV/SARS-CoV-2-infected ferret lungs in short- and long-term models ????Infect Genet Evol http://www.kidney.de/pget.php?&tw=1&pmid=32615317 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32615317 #FOAvip English Wikipedia <ref>{{Cite pmid|32615317}}</ref> Gene signatures of SARS-CoV/SARS-CoV-2-infected ferret lungs in short- and long-term models #MMPMID32615317 Liu HL; Yeh IJ; Phan NN; Wu YH; Yen MC; Hung JH; Chiao CC; Chen CF; Sun Z; Jiang JZ; Hsu HP; Wang CY; Lai MD Infect Genet Evol 2020[Nov]; 85 (ä): 104438 PMID32615317show ga Coronaviruses (CoVs) consist of six strains, and the severe acute respiratory syndrome coronavirus (SARS-CoV), newly found coronavirus (SARS-CoV-2) has rapidly spread leading to a global outbreak. The ferret (Mustela putorius furo) serves as a useful animal model for studying SARS-CoV/SARS-CoV-2 infection and developing therapeutic strategies. A holistic approach for distinguishing differences in gene signatures during disease progression is lacking. The present study discovered gene expression profiles of short-term (3 days) and long-term (14 days) ferret models after SARS-CoV/SARS-CoV-2 infection using a bioinformatics approach. Through Gene Ontology (GO) and MetaCore analyses, we found that the development of stemness signaling was related to short-term SARS-CoV/SARS-CoV-2 infection. In contrast, pathways involving extracellular matrix and immune responses were associated with long-term SARS-CoV/SARS-CoV-2 infection. Some highly expressed genes in both short- and long-term models played a crucial role in the progression of SARS-CoV/SARS-CoV-2 infection, including DPP4, BMP2, NFIA, AXIN2, DAAM1, ZNF608, ME1, MGLL, LGR4, ABHD6, and ACADM. Meanwhile, we revealed that metabolic, glucocorticoid, and reactive oxygen species-associated networks were enriched in both short- and long-term infection models. The present study showed alterations in gene expressions from short-term to long-term SARS-CoV/SARS-CoV-2 infection. The current result provides an explanation of the pathophysiology for post-infectious sequelae and potential targets for treatment. |*Gene Regulatory Networks[MESH] |Animals[MESH] |COVID-19/*genetics/metabolism/virology[MESH] |Computational Biology/methods[MESH] |Disease Models, Animal[MESH] |Disease Progression[MESH] |Ferrets[MESH] |Gene Expression Profiling/*methods[MESH] |Gene Expression Regulation[MESH] |Gene Ontology[MESH] |Lung/*virology[MESH] |Reactive Oxygen Species/metabolism[MESH]Gene signatures of SARS-CoV/SARS-CoV-2-infected ferret lungs in short-(epmc).pdf DeepDyve Pubget Overpricing