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10.1093/infdis/jiaa388

http://scihub22266oqcxt.onion/10.1093/infdis/jiaa388
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32614392!7337834!32614392
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suck abstract from ncbi

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  • Clinical Characteristics and Factors Associated With Long-Term Viral Excretion in Patients With Severe Acute Respiratory Syndrome Coronavirus 2 Infection: a Single-Center 28-Day Study #MMPMID32614392
  • Shi D; Wu W; Wang Q; Xu K; Xie J; Wu J; Lv L; Sheng J; Guo J; Wang K; Fang D; Li Y; Li L
  • J Infect Dis 2020[Aug]; 222 (6): 910-918 PMID32614392show ga
  • BACKGROUND: Despite the ongoing spread of coronavirus disease 2019 (COVID-19), knowledge about factors affecting prolonged viral excretion is limited. METHODS: In this study, we retrospectively collected data from 99 hospitalized patients with coronavirus disease 2019 (COVID-19) between 19 January and 17 February 2020 in Zhejiang Province, China. We classified them into 2 groups based on whether the virus test results eventually became negative. Cox proportional hazards regression was used to evaluate factors associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) shedding. RESULTS: Among 99 patients, 61 patients had SARS-CoV-2 clearance (virus-negative group), but 38 patients had sustained positive results (virus-positive group). The median duration of SARS-CoV-2 excretion was 15 (interquartile range, 12-19) days among the virus-negative patients. The shedding time was significantly increased if the fecal SARS-CoV-2 RNA test result was positive. Male sex (hazard ratio [HR], 0.58 [95% confidence interval {CI}, .35-.98]), immunoglobulin use (HR, 0.42 [95% CI, .24-.76]), APACHE II score (HR, 0.89 [95% CI, .84-.96]), and lymphocyte count (HR, 1.81 [95% CI, 1.05-3.1]) were independent factors associated with a prolonged duration of SARS-CoV-2 shedding. Antiviral therapy and corticosteroid treatment were not independent factors. CONCLUSIONS: SARS-CoV-2 RNA clearance time was associated with sex, disease severity, and lymphocyte function. The current antiviral protocol and low-to-moderate dosage of corticosteroid had little effect on the duration of viral excretion.
  • |*Virus Shedding[MESH]
  • |Adrenal Cortex Hormones/therapeutic use[MESH]
  • |Adult[MESH]
  • |Antiviral Agents/therapeutic use[MESH]
  • |Betacoronavirus/*isolation & purification[MESH]
  • |China[MESH]
  • |Coronavirus Infections/drug therapy/epidemiology/*virology[MESH]
  • |Feces/virology[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Lymphocytes[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/drug therapy/epidemiology/*virology[MESH]
  • |Proportional Hazards Models[MESH]
  • |RNA, Viral/isolation & purification[MESH]
  • |Retrospective Studies[MESH]
  • |Risk Factors[MESH]
  • |Severity of Illness Index[MESH]
  • |Sex Factors[MESH]
  • |Time Factors[MESH]


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  • suck abstract from ncbi

    910 6.222 2020