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10.1039/d0cc03263h

http://scihub22266oqcxt.onion/10.1039/d0cc03263h
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32613971!ä!32613971

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suck abstract from ncbi


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pmid32613971      Chem+Commun+(Camb) 2020 ; 56 (61): 8683-8686
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  • Construction and immunogenic studies of a mFc fusion receptor binding domain (RBD) of spike protein as a subunit vaccine against SARS-CoV-2 infection #MMPMID32613971
  • Qi X; Ke B; Feng Q; Yang D; Lian Q; Li Z; Lu L; Ke C; Liu Z; Liao G
  • Chem Commun (Camb) 2020[Aug]; 56 (61): 8683-8686 PMID32613971show ga
  • Herein, we report that a recombinant fusion protein, containing a 457 amino acid SARS-CoV-2 receptor binding domain (RBD, residues 319-541) and a mouse IgG1 Fc domain, could induce highly potent neutralizing antibodies and stimulate humoral and cellular immunity in mice. The antibodies also effectively suppressed SARS-CoV-2 RBD binding to soluble ACE2, indicating that RBD-mFc may be further developed as a safe and effective SARS-CoV-2 vaccine.
  • |Angiotensin-Converting Enzyme 2[MESH]
  • |Animals[MESH]
  • |Antibodies, Neutralizing/immunology[MESH]
  • |Antibodies, Viral/*immunology[MESH]
  • |Betacoronavirus/drug effects/*immunology[MESH]
  • |COVID-19[MESH]
  • |COVID-19 Vaccines[MESH]
  • |Coronavirus Infections/immunology/*prevention & control/virology[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Mice[MESH]
  • |Mice, Inbred C57BL[MESH]
  • |Pandemics/*prevention & control[MESH]
  • |Peptidyl-Dipeptidase A/metabolism[MESH]
  • |Pneumonia, Viral/immunology/*prevention & control/virology[MESH]
  • |Protein Binding[MESH]
  • |Recombinant Fusion Proteins/*immunology[MESH]
  • |SARS-CoV-2[MESH]
  • |Spike Glycoprotein, Coronavirus/*immunology/metabolism[MESH]
  • |Vaccines, Subunit/*administration & dosage[MESH]


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