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10.3389/fimmu.2020.01446

http://scihub22266oqcxt.onion/10.3389/fimmu.2020.01446
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32612617!7308649!32612617
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suck abstract from ncbi

pmid32612617      Front+Immunol 2020 ; 11 (ä): 1446
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  • The COVID-19 Cytokine Storm; What We Know So Far #MMPMID32612617
  • Ragab D; Salah Eldin H; Taeimah M; Khattab R; Salem R
  • Front Immunol 2020[]; 11 (ä): 1446 PMID32612617show ga
  • COVID-19 is a rapidly spreading global threat that has been declared as a pandemic by the WHO. COVID-19 is transmitted via droplets or direct contact and infects the respiratory tract resulting in pneumonia in most of the cases and acute respiratory distress syndrome (ARDS) in about 15 % of the cases. Mortality in COVID-19 patients has been linked to the presence of the so-called "cytokine storm" induced by the virus. Excessive production of proinflammatory cytokines leads to ARDS aggravation and widespread tissue damage resulting in multi-organ failure and death. Targeting cytokines during the management of COVID-19 patients could improve survival rates and reduce mortality.
  • |Antibodies, Monoclonal, Humanized/therapeutic use[MESH]
  • |Betacoronavirus/immunology[MESH]
  • |COVID-19[MESH]
  • |COVID-19 Drug Treatment[MESH]
  • |Coronavirus Infections/*drug therapy/immunology/*pathology[MESH]
  • |Cytokine Release Syndrome/*drug therapy/immunology/*pathology[MESH]
  • |Cytokines/blood[MESH]
  • |Humans[MESH]
  • |Interleukin-6/antagonists & inhibitors[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*drug therapy/immunology/*pathology[MESH]
  • |Receptors, Interleukin-6/antagonists & inhibitors[MESH]
  • |Respiratory Distress Syndrome/drug therapy/pathology/*prevention & control[MESH]


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