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10.3389/fimmu.2020.01441 http://scihub22266oqcxt.onion/10.3389/fimmu.2020.01441 32612615!7308593!32612615     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Immunol 2020 ; 11 (ä): 1441 Nephropedia Template TP {{tp|p=32612615|t=2020. Immune Response, Inflammation, and the Clinical Spectrum of COVID-19 |pdf=|usr=}}{{32612615}} gab.com Text Immune Response, Inflammation, and the Clinical Spectrum of COVID-19 JO: Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=32612615 #FOAvip The current COVID-19 pandemic began in December 2019 in Wuhan (China) and rapidly extended to become a global sanitary and economic emergency. Its etiological agent is the coronavirus SARS-CoV-2. COVID-19 presents a wide spectrum of clinical manifestations, which ranges from an asymptomatic infection to a severe pneumonia accompanied by multisystemic failure that can lead to a patient's death. The immune response to SARS-CoV-2 is known to involve all the components of the immune system that together appear responsible for viral elimination and recovery from the infection. Nonetheless, such immune responses are implicated in the disease's progression to a more severe and lethal process. This review describes the general aspects of both COVID-19 and its etiological agent SARS-CoV-2, stressing the similarities with other severe coronavirus infections, such as SARS and MERS, but more importantly, pointing toward the evidence supporting the hypothesis that the clinical spectrum of COVID-19 is a consequence of the corresponding variable spectrum of the immune responses to the virus. The critical point where progression of the disease ensues appears to center on loss of the immune regulation between protective and altered responses due to exacerbation of the inflammatory components. Finally, it appears possible to delineate certain major challenges deserving of exhaustive investigation to further understand COVID-19 immunopathogenesis, thus helping to design more effective diagnostic, therapeutic, and prophylactic strategies. Twit Text FOAVip Immune Response, Inflammation, and the Clinical Spectrum of COVID-19 ????Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=32612615 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32612615 #FOAvip English Wikipedia <ref>{{Cite pmid|32612615}}</ref> Immune Response, Inflammation, and the Clinical Spectrum of COVID-19 #MMPMID32612615 Garcia LF Front Immunol 2020[]; 11 (ä): 1441 PMID32612615show ga The current COVID-19 pandemic began in December 2019 in Wuhan (China) and rapidly extended to become a global sanitary and economic emergency. Its etiological agent is the coronavirus SARS-CoV-2. COVID-19 presents a wide spectrum of clinical manifestations, which ranges from an asymptomatic infection to a severe pneumonia accompanied by multisystemic failure that can lead to a patient's death. The immune response to SARS-CoV-2 is known to involve all the components of the immune system that together appear responsible for viral elimination and recovery from the infection. Nonetheless, such immune responses are implicated in the disease's progression to a more severe and lethal process. This review describes the general aspects of both COVID-19 and its etiological agent SARS-CoV-2, stressing the similarities with other severe coronavirus infections, such as SARS and MERS, but more importantly, pointing toward the evidence supporting the hypothesis that the clinical spectrum of COVID-19 is a consequence of the corresponding variable spectrum of the immune responses to the virus. The critical point where progression of the disease ensues appears to center on loss of the immune regulation between protective and altered responses due to exacerbation of the inflammatory components. Finally, it appears possible to delineate certain major challenges deserving of exhaustive investigation to further understand COVID-19 immunopathogenesis, thus helping to design more effective diagnostic, therapeutic, and prophylactic strategies. |Age Factors[MESH] |Antibodies, Viral/immunology[MESH] |Antibody-Dependent Enhancement/immunology[MESH] |Betacoronavirus/classification/genetics/*immunology[MESH] |COVID-19[MESH] |Coronavirus Infections/diagnosis/*immunology/*pathology[MESH] |Cytokines/blood[MESH] |Humans[MESH] |Immunoglobulin A, Secretory/immunology[MESH] |Inflammation/pathology[MESH] |Macrophages/immunology[MESH] |Pandemics[MESH] |Pneumonia, Viral/diagnosis/*immunology/*pathology[MESH] |SARS-CoV-2[MESH]Immune Response, Inflammation, and the Clinical Spectrum of COVID-19 (epmc).pdf DeepDyve Pubget Overpricing