Neuromechanisms of SARS-CoV-2: A Review #MMPMID32612515
DosSantos MF; Devalle S; Aran V; Capra D; Roque NR; Coelho-Aguiar JM; Spohr TCLSE; Subilhaga JG; Pereira CM; D'Andrea Meira I; Niemeyer Soares Filho P; Moura-Neto V
Front Neuroanat 2020[]; 14 (ä): 37 PMID32612515show ga
Recent studies have suggested the neuroinvasive potential of severe acute respiratory coronavirus 2 (SARS-CoV-2). Notably, neuroinvasiveness might be involved in the pathophysiology of coronavirus disease 2019 (COVID-19). Some studies have demonstrated that synapse-connected routes may enable coronaviruses to access the central nervous system (CNS). However, evidence related to the presence of SARS-CoV-2 in the CNS, its direct impact on the CNS, and the contribution to symptoms suffered, remain sparse. Here, we review the current literature that indicates that SARS-CoV-2 can invade the nervous system. We also describe the neural circuits that are potentially affected by the virus and their possible role in the progress of COVID-19. In addition, we propose several strategies to understand, diagnose, and treat the neurological symptoms of COVID-19.