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10.1136/jitc-2020-001145

http://scihub22266oqcxt.onion/10.1136/jitc-2020-001145
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32611687!7358098!32611687
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suck abstract from ncbi


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pmid32611687      J+Immunother+Cancer 2020 ; 8 (2): ä
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  • On the use of immune checkpoint inhibitors in patients with viral infections including COVID-19 #MMPMID32611687
  • Gambichler T; Reuther J; Scheel CH; Becker JC
  • J Immunother Cancer 2020[Jul]; 8 (2): ä PMID32611687show ga
  • The present review summarizes up-to-date evidence addressing the frequently discussed clinical controversies regarding the use of immune checkpoint inhibitors (ICIs) in cancer patients with viral infections, including AIDS, hepatitis B and C, progressive multifocal leukoencephalopathy, influenza, and COVID-19. In detail, we provide available information on (1) safety regarding the risk of new infections, (2) effects on the outcome of pre-existing infections, (3) whether immunosuppressive drugs used to treat ICI-related adverse events affect the risk of infection or virulence of pre-existing infections, (4) whether the use of vaccines in ICI-treated patients is considered safe, and (5) whether there are beneficial effects of ICIs that even qualify them as a therapeutic approach for these viral infections.
  • |Betacoronavirus[MESH]
  • |COVID-19[MESH]
  • |Coronavirus Infections/complications/drug therapy/immunology/therapy[MESH]
  • |Hepatitis B/complications/drug therapy/immunology/therapy[MESH]
  • |Hepatitis C/complications/drug therapy/immunology/therapy[MESH]
  • |Humans[MESH]
  • |Immunosuppressive Agents/*therapeutic use[MESH]
  • |Influenza, Human/complications/drug therapy/immunology/therapy[MESH]
  • |Neoplasms/*complications[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/complications/drug therapy/immunology/therapy[MESH]
  • |SARS-CoV-2[MESH]


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