Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1016/j.cmet.2020.06.016 http://scihub22266oqcxt.onion/10.1016/j.cmet.2020.06.016 32610096!7311890!32610096     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Metab 2020 ; 32 (2): 188-202.e5 Nephropedia Template TP {{tp|p=32610096|t=2020. Omics-Driven Systems Interrogation of Metabolic Dysregulation in COVID-19 Pathogenesis |pdf=|usr=}}{{32610096}} gab.com Text Omics-Driven Systems Interrogation of Metabolic Dysregulation in COVID-19 Pathogenesis JO: Cell Metab http://www.kidney.de/pget.php?&tw=1&pmid=32610096 #FOAvip The coronavirus disease 2019 (COVID-19) pandemic presents an unprecedented threat to global public health. Herein, we utilized a combination of targeted and untargeted tandem mass spectrometry to analyze the plasma lipidome and metabolome in mild, moderate, and severe COVID-19 patients and healthy controls. A panel of 10 plasma metabolites effectively distinguished COVID-19 patients from healthy controls (AUC = 0.975). Plasma lipidome of COVID-19 resembled that of monosialodihexosyl ganglioside (GM3)-enriched exosomes, with enhanced levels of sphingomyelins (SMs) and GM3s, and reduced diacylglycerols (DAGs). Systems evaluation of metabolic dysregulation in COVID-19 was performed using multiscale embedded differential correlation network analyses. Using exosomes isolated from the same cohort, we demonstrated that exosomes of COVID-19 patients with elevating disease severity were increasingly enriched in GM3s. Our work suggests that GM3-enriched exosomes may partake in pathological processes related to COVID-19 pathogenesis and presents the largest repository on the plasma lipidome and metabolome distinct to COVID-19. Twit Text FOAVip Omics-Driven Systems Interrogation of Metabolic Dysregulation in COVID-19 Pathogenesis ????Cell Metab http://www.kidney.de/pget.php?&tw=1&pmid=32610096 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32610096 #FOAvip English Wikipedia <ref>{{Cite pmid|32610096}}</ref> Omics-Driven Systems Interrogation of Metabolic Dysregulation in COVID-19 Pathogenesis #MMPMID32610096 Song JW; Lam SM; Fan X; Cao WJ; Wang SY; Tian H; Chua GH; Zhang C; Meng FP; Xu Z; Fu JL; Huang L; Xia P; Yang T; Zhang S; Li B; Jiang TJ; Wang R; Wang Z; Shi M; Zhang JY; Wang FS; Shui G Cell Metab 2020[Aug]; 32 (2): 188-202.e5 PMID32610096show ga The coronavirus disease 2019 (COVID-19) pandemic presents an unprecedented threat to global public health. Herein, we utilized a combination of targeted and untargeted tandem mass spectrometry to analyze the plasma lipidome and metabolome in mild, moderate, and severe COVID-19 patients and healthy controls. A panel of 10 plasma metabolites effectively distinguished COVID-19 patients from healthy controls (AUC = 0.975). Plasma lipidome of COVID-19 resembled that of monosialodihexosyl ganglioside (GM3)-enriched exosomes, with enhanced levels of sphingomyelins (SMs) and GM3s, and reduced diacylglycerols (DAGs). Systems evaluation of metabolic dysregulation in COVID-19 was performed using multiscale embedded differential correlation network analyses. Using exosomes isolated from the same cohort, we demonstrated that exosomes of COVID-19 patients with elevating disease severity were increasingly enriched in GM3s. Our work suggests that GM3-enriched exosomes may partake in pathological processes related to COVID-19 pathogenesis and presents the largest repository on the plasma lipidome and metabolome distinct to COVID-19. |Adult[MESH] |Aged[MESH] |Betacoronavirus[MESH] |CD4-Positive T-Lymphocytes/immunology/pathology[MESH] |COVID-19[MESH] |Coronavirus Infections/*blood/*pathology[MESH] |Diglycerides/blood[MESH] |Exosomes/*metabolism[MESH] |Female[MESH] |G(M3) Ganglioside/*blood[MESH] |Gangliosides/*blood[MESH] |Humans[MESH] |Male[MESH] |Metabolome/physiology[MESH] |Metabolomics/methods[MESH] |Middle Aged[MESH] |Pandemics[MESH] |Pneumonia, Viral/*blood/*pathology[MESH] |SARS-CoV-2[MESH] |Sphingomyelins/blood[MESH] |Tandem Mass Spectrometry[MESH]Omics-Driven Systems Interrogation of Metabolic Dysregulation in COVID(epmc).pdf DeepDyve Pubget Overpricing