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10.1182/bloodadvances.2020001640 http://scihub22266oqcxt.onion/10.1182/bloodadvances.2020001640 32609845!7362372!32609845     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Blood+Adv 2020 ; 4 (13): 2967-2978 Nephropedia Template TP {{tp|p=32609845|t=2020. Influenza-induced thrombocytopenia is dependent on the subtype and sialoglycan receptor and increases with virus pathogenicity |pdf=|usr=}}{{32609845}} gab.com Text Influenza-induced thrombocytopenia is dependent on the subtype and sialoglycan receptor and increases with virus pathogenicity JO: Blood Adv http://www.kidney.de/pget.php?&tw=1&pmid=32609845 #FOAvip Thrombocytopenia is a common complication of influenza virus infection, and its severity predicts the clinical outcome of critically ill patients. The underlying cause(s) remain incompletely understood. In this study, in patients with an influenza A/H1N1 virus infection, viral load and platelet count correlated inversely during the acute infection phase. We confirmed this finding in a ferret model of influenza virus infection. In these animals, platelet count decreased with the degree of virus pathogenicity varying from 0% in animals infected with the influenza A/H3N2 virus, to 22% in those with the pandemic influenza A/H1N1 virus, up to 62% in animals with a highly pathogenic A/H5N1 virus infection. This thrombocytopenia is associated with virus-containing platelets that circulate in the blood. Uptake of influenza virus particles by platelets requires binding to sialoglycans and results in the removal of sialic acids by the virus neuraminidase, a trigger for hepatic clearance of platelets. We propose the clearance of influenza virus by platelets as a paradigm. These insights clarify the pathophysiology of influenza virus infection and show how severe respiratory infections, including COVID-19, may propagate thrombocytopenia and/or thromboembolic complications. Twit Text FOAVip Influenza-induced thrombocytopenia is dependent on the subtype and sialoglycan receptor and increases with virus pathogenicity ????Blood Adv http://www.kidney.de/pget.php?&tw=1&pmid=32609845 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32609845 #FOAvip English Wikipedia <ref>{{Cite pmid|32609845}}</ref> Influenza-induced thrombocytopenia is dependent on the subtype and sialoglycan receptor and increases with virus pathogenicity #MMPMID32609845 Jansen AJG; Spaan T; Low HZ; Di Iorio D; van den Brand J; Tieke M; Barendrecht A; Rohn K; van Amerongen G; Stittelaar K; Baumgartner W; Osterhaus A; Kuiken T; Boons GJ; Huskens J; Boes M; Maas C; van der Vries E Blood Adv 2020[Jul]; 4 (13): 2967-2978 PMID32609845show ga Thrombocytopenia is a common complication of influenza virus infection, and its severity predicts the clinical outcome of critically ill patients. The underlying cause(s) remain incompletely understood. In this study, in patients with an influenza A/H1N1 virus infection, viral load and platelet count correlated inversely during the acute infection phase. We confirmed this finding in a ferret model of influenza virus infection. In these animals, platelet count decreased with the degree of virus pathogenicity varying from 0% in animals infected with the influenza A/H3N2 virus, to 22% in those with the pandemic influenza A/H1N1 virus, up to 62% in animals with a highly pathogenic A/H5N1 virus infection. This thrombocytopenia is associated with virus-containing platelets that circulate in the blood. Uptake of influenza virus particles by platelets requires binding to sialoglycans and results in the removal of sialic acids by the virus neuraminidase, a trigger for hepatic clearance of platelets. We propose the clearance of influenza virus by platelets as a paradigm. These insights clarify the pathophysiology of influenza virus infection and show how severe respiratory infections, including COVID-19, may propagate thrombocytopenia and/or thromboembolic complications. |Animals[MESH] |Blood Platelets/metabolism/pathology/*virology[MESH] |Disease Models, Animal[MESH] |Ferrets[MESH] |Host-Pathogen Interactions[MESH] |Humans[MESH] |Influenza A Virus, H1N1 Subtype/pathogenicity/physiology[MESH] |Influenza A Virus, H3N2 Subtype/pathogenicity/physiology[MESH] |Influenza A Virus, H5N1 Subtype/pathogenicity/physiology[MESH] |Influenza A virus/*pathogenicity/physiology[MESH] |Influenza, Human/*complications/metabolism/pathology/virology[MESH] |N-Acetylneuraminic Acid/*metabolism[MESH] |Orthomyxoviridae Infections/complications/metabolism/pathology/virology[MESH] |Polysaccharides/*metabolism[MESH] |Thrombocytopenia/*etiology/metabolism/pathology/virology[MESH]Influenza-induced thrombocytopenia is dependent on the subtype and sia(epmc).pdf DeepDyve Pubget Overpricing