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10.1186/s13017-020-00323-2 http://scihub22266oqcxt.onion/10.1186/s13017-020-00323-2 32605582!7324776!32605582     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       World+J+Emerg+Surg 2020 ; 15 (1): 41 Nephropedia Template TP {{tp|p=32605582|t=2020. Iron metabolism and lymphocyte characterisation during Covid-19 infection in ICU patients: an observational cohort study |pdf=|usr=}}{{32605582}} gab.com Text Iron metabolism and lymphocyte characterisation during Covid-19 infection in ICU patients: an observational cohort study JO: World J Emerg Surg http://www.kidney.de/pget.php?&tw=1&pmid=32605582 #FOAvip BACKGROUND: Iron metabolism and immune response to SARS-CoV-2 have not been described yet in intensive care patients, although they are likely involved in Covid-19 pathogenesis. METHODS: We performed an observational study during the peak of pandemic in our intensive care unit, dosing D-dimer, C-reactive protein, troponin T, lactate dehydrogenase, ferritin, serum iron, transferrin, transferrin saturation, transferrin soluble receptor, lymphocyte count and NK, CD3, CD4, CD8 and B subgroups of 31 patients during the first 2 weeks of their ICU stay. Correlation with mortality and severity at the time of admission was tested with the Spearman coefficient and Mann-Whitney test. Trends over time were tested with the Kruskal-Wallis analysis. RESULTS: Lymphopenia is severe and constant, with a nadir on day 2 of ICU stay (median 0.555 10(9)/L; interquartile range (IQR) 0.450 10(9)/L); all lymphocytic subgroups are dramatically reduced in critically ill patients, while CD4/CD8 ratio remains normal. Neither ferritin nor lymphocyte count follows significant trends in ICU patients. Transferrin saturation is extremely reduced at ICU admission (median 9%; IQR 7%), then significantly increases at days 3 to 6 (median 33%, IQR 26.5%, p value 0.026). The same trend is observed with serum iron levels (median 25.5 mug/L, IQR 69 mug/L at admission; median 73 mug/L, IQR 56 mug/L on days 3 to 6) without reaching statistical significance. Hyperferritinemia is constant during intensive care stay: however, its dosage might be helpful in individuating patients developing haemophagocytic lymphohistiocytosis. D-dimer is elevated and progressively increases from admission (median 1319 mug/L; IQR 1285 mug/L) to days 3 to 6 (median 6820 mug/L; IQR 6619 mug/L), despite not reaching significant results. We describe trends of all the abovementioned parameters during ICU stay. CONCLUSIONS: The description of iron metabolism and lymphocyte count in Covid-19 patients admitted to the intensive care unit provided with this paper might allow a wider understanding of SARS-CoV-2 pathophysiology. Twit Text FOAVip Iron metabolism and lymphocyte characterisation during Covid-19 infection in ICU patients: an observational cohort study ????World J Emerg Surg http://www.kidney.de/pget.php?&tw=1&pmid=32605582 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32605582 #FOAvip English Wikipedia <ref>{{Cite pmid|32605582}}</ref> Iron metabolism and lymphocyte characterisation during Covid-19 infection in ICU patients: an observational cohort study #MMPMID32605582 Bolondi G; Russo E; Gamberini E; Circelli A; Meca MCC; Brogi E; Viola L; Bissoni L; Poletti V; Agnoletti V World J Emerg Surg 2020[Jun]; 15 (1): 41 PMID32605582show ga BACKGROUND: Iron metabolism and immune response to SARS-CoV-2 have not been described yet in intensive care patients, although they are likely involved in Covid-19 pathogenesis. METHODS: We performed an observational study during the peak of pandemic in our intensive care unit, dosing D-dimer, C-reactive protein, troponin T, lactate dehydrogenase, ferritin, serum iron, transferrin, transferrin saturation, transferrin soluble receptor, lymphocyte count and NK, CD3, CD4, CD8 and B subgroups of 31 patients during the first 2 weeks of their ICU stay. Correlation with mortality and severity at the time of admission was tested with the Spearman coefficient and Mann-Whitney test. Trends over time were tested with the Kruskal-Wallis analysis. RESULTS: Lymphopenia is severe and constant, with a nadir on day 2 of ICU stay (median 0.555 10(9)/L; interquartile range (IQR) 0.450 10(9)/L); all lymphocytic subgroups are dramatically reduced in critically ill patients, while CD4/CD8 ratio remains normal. Neither ferritin nor lymphocyte count follows significant trends in ICU patients. Transferrin saturation is extremely reduced at ICU admission (median 9%; IQR 7%), then significantly increases at days 3 to 6 (median 33%, IQR 26.5%, p value 0.026). The same trend is observed with serum iron levels (median 25.5 mug/L, IQR 69 mug/L at admission; median 73 mug/L, IQR 56 mug/L on days 3 to 6) without reaching statistical significance. Hyperferritinemia is constant during intensive care stay: however, its dosage might be helpful in individuating patients developing haemophagocytic lymphohistiocytosis. D-dimer is elevated and progressively increases from admission (median 1319 mug/L; IQR 1285 mug/L) to days 3 to 6 (median 6820 mug/L; IQR 6619 mug/L), despite not reaching significant results. We describe trends of all the abovementioned parameters during ICU stay. CONCLUSIONS: The description of iron metabolism and lymphocyte count in Covid-19 patients admitted to the intensive care unit provided with this paper might allow a wider understanding of SARS-CoV-2 pathophysiology. |*Coronavirus Infections/blood/mortality/physiopathology/therapy[MESH] |*Critical Care/methods/statistics & numerical data[MESH] |*Pandemics[MESH] |*Pneumonia, Viral/blood/mortality/physiopathology/therapy[MESH] |Aged[MESH] |Betacoronavirus/isolation & purification[MESH] |Blood Coagulation[MESH] |COVID-19[MESH] |Correlation of Data[MESH] |Female[MESH] |Humans[MESH] |Intensive Care Units/statistics & numerical data[MESH] |Iron/*metabolism[MESH] |Italy/epidemiology[MESH] |Lymphocyte Count/methods[MESH] |Lymphocyte Subsets[MESH] |Lymphocytes/*immunology[MESH] |Male[MESH] |Middle Aged[MESH] |Mortality[MESH] |SARS-CoV-2[MESH] |Severity of Illness Index[MESH]Iron metabolism and lymphocyte characterisation during Covid-19 infect(epmc).pdf DeepDyve Pubget Overpricing