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Calcineurin inhibitors revisited: A new paradigm for COVID-19? #MMPMID32603679
Hage R; Steinack C; Schuurmans MM
Braz J Infect Dis 2020[Jul]; 24 (4): 365-367 PMID32603679show ga
The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) can cause mild, moderate or severe disease (COVID-19). In severe disease, there is hyperinflammation causing severe symptoms. Severe COVID-19 is an immunological phenomenon, rather than a direct viral damage disease. Therapies for COVID-19 are all investigational therapies. In case of severe disease, treatment with a calcineurin inhibitor could be promising. In this article we explain the mechanisms of calcineurin inhibitor treatment for COVID-19, based on experiences seen in solid organ transplant recipients who suffered from COVID-19.