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10.1111/apha.13528 http://scihub22266oqcxt.onion/10.1111/apha.13528 32603001!7816272!32603001     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Acta+Physiol+(Oxf) 2021 ; 231 (2): e13528 Nephropedia Template TP {{tp|p=32603001|t=2021. Mechanisms coupling sodium and magnesium reabsorption in the distal convoluted tubule of the kidney |pdf=|usr=}}{{32603001}} gab.com Text Mechanisms coupling sodium and magnesium reabsorption in the distal convoluted tubule of the kidney JO: Acta Physiol (Oxf) http://www.kidney.de/pget.php?&tw=1&pmid=32603001 #FOAvip Hypomagnesaemia is a common feature of renal Na(+) wasting disorders such as Gitelman and EAST/SeSAME syndrome. These genetic defects specifically affect Na(+) reabsorption in the distal convoluted tubule, where Mg(2+) reabsorption is tightly regulated. Apical uptake via TRPM6 Mg(2+) channels and basolateral Mg(2+) extrusion via a putative Na(+) -Mg(2+) exchanger determines Mg(2+) reabsorption in the distal convoluted tubule. However, the mechanisms that explain the high incidence of hypomagnesaemia in patients with Na(+) wasting disorders of the distal convoluted tubule are largely unknown. In this review, we describe three potential mechanisms by which Mg(2+) reabsorption in the distal convoluted tubule is linked to Na(+) reabsorption. First, decreased activity of the thiazide-sensitive Na(+) /Cl(-) cotransporter (NCC) results in shortening of the segment, reducing the Mg(2+) reabsorption capacity. Second, the activity of TRPM6 and NCC are determined by common regulatory pathways. Secondary effects of NCC dysregulation such as hormonal imbalance, therefore, might disturb TRPM6 expression. Third, the basolateral membrane potential, maintained by the K(+) permeability and Na(+) -K(+) -ATPase activity, provides the driving force for Na(+) and Mg(2+) extrusion. Depolarisation of the basolateral membrane potential in Na(+) wasting disorders of the distal convoluted tubule may therefore lead to reduced activity of the putative Na(+) -Mg(2+) exchanger SLC41A1. Elucidating the interconnections between Mg(2+) and Na(+) transport in the distal convoluted tubule is hampered by the currently available models. Our analysis indicates that the coupling of Na(+) and Mg(2+) reabsorption may be multifactorial and that advanced experimental models are required to study the molecular mechanisms. Twit Text FOAVip Mechanisms coupling sodium and magnesium reabsorption in the distal convoluted tubule of the kidney ????Acta Physiol (Oxf) http://www.kidney.de/pget.php?&tw=1&pmid=32603001 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32603001 #FOAvip English Wikipedia <ref>{{Cite pmid|32603001}}</ref> Mechanisms coupling sodium and magnesium reabsorption in the distal convoluted tubule of the kidney #MMPMID32603001 Franken GAC; Adella A; Bindels RJM; de Baaij JHF Acta Physiol (Oxf) 2021[Feb]; 231 (2): e13528 PMID32603001show ga Hypomagnesaemia is a common feature of renal Na(+) wasting disorders such as Gitelman and EAST/SeSAME syndrome. These genetic defects specifically affect Na(+) reabsorption in the distal convoluted tubule, where Mg(2+) reabsorption is tightly regulated. Apical uptake via TRPM6 Mg(2+) channels and basolateral Mg(2+) extrusion via a putative Na(+) -Mg(2+) exchanger determines Mg(2+) reabsorption in the distal convoluted tubule. However, the mechanisms that explain the high incidence of hypomagnesaemia in patients with Na(+) wasting disorders of the distal convoluted tubule are largely unknown. In this review, we describe three potential mechanisms by which Mg(2+) reabsorption in the distal convoluted tubule is linked to Na(+) reabsorption. First, decreased activity of the thiazide-sensitive Na(+) /Cl(-) cotransporter (NCC) results in shortening of the segment, reducing the Mg(2+) reabsorption capacity. Second, the activity of TRPM6 and NCC are determined by common regulatory pathways. Secondary effects of NCC dysregulation such as hormonal imbalance, therefore, might disturb TRPM6 expression. Third, the basolateral membrane potential, maintained by the K(+) permeability and Na(+) -K(+) -ATPase activity, provides the driving force for Na(+) and Mg(2+) extrusion. Depolarisation of the basolateral membrane potential in Na(+) wasting disorders of the distal convoluted tubule may therefore lead to reduced activity of the putative Na(+) -Mg(2+) exchanger SLC41A1. Elucidating the interconnections between Mg(2+) and Na(+) transport in the distal convoluted tubule is hampered by the currently available models. Our analysis indicates that the coupling of Na(+) and Mg(2+) reabsorption may be multifactorial and that advanced experimental models are required to study the molecular mechanisms. |*Magnesium/metabolism[MESH] |*Sodium/metabolism[MESH] |Biological Transport[MESH] |Humans[MESH] |Kidney Tubules, Distal/metabolism[MESH]Mechanisms coupling sodium and magnesium reabsorption in the distal co(epmc).pdf DeepDyve Pubget Overpricing