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10.1002/rmv.2122

http://scihub22266oqcxt.onion/10.1002/rmv.2122
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32602627!7361198!32602627
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suck abstract from ncbi


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pmid32602627      Rev+Med+Virol 2020 ; 30 (5): e2122
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  • Angiotensin-converting enzyme 2: The old door for new severe acute respiratory syndrome coronavirus 2 infection #MMPMID32602627
  • Tan HW; Xu YM; Lau ATY
  • Rev Med Virol 2020[Sep]; 30 (5): e2122 PMID32602627show ga
  • Coronavirus (CoV) disease 2019 (COVID-19) is an ongoing pandemic caused by severe acute respiratory syndrome CoV 2 (SARS-CoV-2). The highly contagious SARS-CoV-2 belongs to the genus Betacoronavirus, and it is phylogenetically closely related to SARS-CoV, a human CoV that caused an outbreak back in 2002 to 2003. Both SARS-CoV-2 and SARS-CoV enter human cells via the interactions between viral crown-like spike protein and human angiotensin-converting enzyme 2 (ACE2) receptor. Here, we aim to review the involvement of ACE2 in human CoV infections by discussing the roles of ACE2 in CoV evolution, cross-species transmissibility, and COVID-19 susceptibility. We also provide our perspectives on COVID-19 treatment and prevention.
  • |Angiotensin-Converting Enzyme 2[MESH]
  • |Animals[MESH]
  • |Betacoronavirus/classification/*genetics/pathogenicity[MESH]
  • |Biological Evolution[MESH]
  • |COVID-19[MESH]
  • |Chiroptera/virology[MESH]
  • |Coronavirus Infections/physiopathology/*virology[MESH]
  • |Eutheria/virology[MESH]
  • |Gene Expression Regulation[MESH]
  • |Humans[MESH]
  • |Pandemics[MESH]
  • |Peptidyl-Dipeptidase A/*genetics/metabolism[MESH]
  • |Phylogeny[MESH]
  • |Pneumonia, Viral/physiopathology/*virology[MESH]
  • |Protein Binding[MESH]
  • |Receptors, Virus/*genetics/metabolism[MESH]
  • |SARS-CoV-2[MESH]
  • |Severe Acute Respiratory Syndrome/physiopathology/virology[MESH]
  • |Severe acute respiratory syndrome-related coronavirus/classification/*genetics/pathogenicity[MESH]
  • |Spike Glycoprotein, Coronavirus/*genetics/metabolism[MESH]


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