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10.1002/art.41422

http://scihub22266oqcxt.onion/10.1002/art.41422
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32602262!7361793!32602262
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suck abstract from ncbi


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pmid32602262      Arthritis+Rheumatol 2020 ; 72 (12): 1990-1997
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  • Use of Anakinra to Prevent Mechanical Ventilation in Severe COVID-19: A Case Series #MMPMID32602262
  • Navarro-Millan I; Sattui SE; Lakhanpal A; Zisa D; Siegel CH; Crow MK
  • Arthritis Rheumatol 2020[Dec]; 72 (12): 1990-1997 PMID32602262show ga
  • OBJECTIVE: To report the clinical experience with anakinra in preventing mechanical ventilation in patients with coronavirus disease 2019 (COVID-19), symptoms of cytokine storm syndrome, and acute hypoxemic respiratory failure. METHODS: To be included in this retrospective case series, patients must have had severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), fever, ferritin levels >1,000 ng/ml with 1 additional laboratory marker of hyperinflammation, and acute hypoxemic respiratory failure. Acute hypoxemic respiratory failure was defined as requiring 15 liters of supplemental oxygen via a nonrebreather mask combined with 6-liter nasal cannula or use of >/=95% oxygen by high-flow nasal cannula. We excluded patients in whom there was suspicion of bacterial infection or who were receiving immunosuppressants. Subcutaneous anakinra was initiated at 100 mg every 6 hours and gradually tapered off completely. The primary outcome was the prevention of mechanical ventilation. RESULTS: Of the 14 patients who met the criteria, 11 patients received anakinra for a maximum of 19 days. Seven of the patients who started anakinra treatment /=4 days after onset of acute hypoxemic respiratory failure required mechanical ventilation. Of those, 3 patients were extubated (2 discharged home and 1 remained hospitalized), and 1 died. All 3 patients who met the criteria but did not receive anakinra required mechanical ventilation. Two patients were extubated (1 discharged home and 1 remained hospitalized), and 1 remained on mechanical ventilation. CONCLUSION: Our data suggest that anakinra could be beneficial in treating COVID-19 patients with evidence of cytokine storm syndrome when initiated early after onset of acute hypoxemic respiratory failure. Our patient selection and treatment approach should be considered for investigation in a clinical trial to determine the safety and efficacy of anakinra in treating patients with COVID-19 and symptoms of cytokine storm syndrome.
  • |*Respiration, Artificial[MESH]
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |Antirheumatic Agents/*therapeutic use[MESH]
  • |COVID-19 Drug Treatment[MESH]
  • |COVID-19/*therapy[MESH]
  • |Cytokine Release Syndrome/drug therapy/*therapy[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Interleukin 1 Receptor Antagonist Protein/*therapeutic use[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Respiratory Insufficiency/drug therapy/*therapy[MESH]
  • |Retrospective Studies[MESH]


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