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10.1038/s41598-020-66716-0 http://scihub22266oqcxt.onion/10.1038/s41598-020-66716-0 32601278!7324389!32601278     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2020 ; 10 (1): 10568 Nephropedia Template TP {{tp|p=32601278|t=2020. Numerical evaluation of spray position for improved nasal drug delivery |pdf=|usr=}}{{32601278}} gab.com Text Numerical evaluation of spray position for improved nasal drug delivery JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=32601278 #FOAvip Topical intra-nasal sprays are amongst the most commonly prescribed therapeutic options for sinonasal diseases in humans. However, inconsistency and ambiguity in instructions show a lack of definitive knowledge on best spray use techniques. In this study, we have identified a new usage strategy for nasal sprays available over-the-counter, that registers an average 8-fold improvement in topical delivery of drugs at diseased sites, when compared to prevalent spray techniques. The protocol involves re-orienting the spray axis to harness inertial motion of particulates and has been developed using computational fluid dynamics simulations of respiratory airflow and droplet transport in medical imaging-based digital models. Simulated dose in representative models is validated through in vitro spray measurements in 3D-printed anatomic replicas using the gamma scintigraphy technique. This work breaks new ground in proposing an alternative user-friendly strategy that can significantly enhance topical delivery inside human nose. While these findings can eventually translate into personalized spray usage instructions and hence merit a change in nasal standard-of-care, this study also demonstrates how relatively simple engineering analysis tools can revolutionize everyday healthcare. Finally, with respiratory mucosa as the initial coronavirus infection site, our findings are relevant to intra-nasal vaccines that are in-development, to mitigate the COVID-19 pandemic. Twit Text FOAVip Numerical evaluation of spray position for improved nasal drug delivery ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=32601278 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32601278 #FOAvip English Wikipedia <ref>{{Cite pmid|32601278}}</ref> Numerical evaluation of spray position for improved nasal drug delivery #MMPMID32601278 Basu S; Holbrook LT; Kudlaty K; Fasanmade O; Wu J; Burke A; Langworthy BW; Farzal Z; Mamdani M; Bennett WD; Fine JP; Senior BA; Zanation AM; Ebert CS Jr; Kimple AJ; Thorp BD; Frank-Ito DO; Garcia GJM; Kimbell JS Sci Rep 2020[Jun]; 10 (1): 10568 PMID32601278show ga Topical intra-nasal sprays are amongst the most commonly prescribed therapeutic options for sinonasal diseases in humans. However, inconsistency and ambiguity in instructions show a lack of definitive knowledge on best spray use techniques. In this study, we have identified a new usage strategy for nasal sprays available over-the-counter, that registers an average 8-fold improvement in topical delivery of drugs at diseased sites, when compared to prevalent spray techniques. The protocol involves re-orienting the spray axis to harness inertial motion of particulates and has been developed using computational fluid dynamics simulations of respiratory airflow and droplet transport in medical imaging-based digital models. Simulated dose in representative models is validated through in vitro spray measurements in 3D-printed anatomic replicas using the gamma scintigraphy technique. This work breaks new ground in proposing an alternative user-friendly strategy that can significantly enhance topical delivery inside human nose. While these findings can eventually translate into personalized spray usage instructions and hence merit a change in nasal standard-of-care, this study also demonstrates how relatively simple engineering analysis tools can revolutionize everyday healthcare. Finally, with respiratory mucosa as the initial coronavirus infection site, our findings are relevant to intra-nasal vaccines that are in-development, to mitigate the COVID-19 pandemic. |*Administration, Inhalation[MESH] |*Betacoronavirus[MESH] |*Nasal Sprays[MESH] |Administration, Intranasal/*methods[MESH] |COVID-19[MESH] |Computer Simulation[MESH] |Coronavirus Infections/*prevention & control/virology[MESH] |Drug Delivery Systems/*methods[MESH] |Humans[MESH] |Hydrodynamics[MESH] |Nasal Cavity/anatomy & histology[MESH] |Nasal Mucosa/drug effects/virology[MESH] |Nebulizers and Vaporizers[MESH] |Pandemics/*prevention & control[MESH] |Paranasal Sinuses/drug effects/virology[MESH] |Pneumonia, Viral/*prevention & control/virology[MESH] |SARS-CoV-2[MESH]Numerical evaluation of spray position for improved nasal drug deliver(epmc).pdf DeepDyve Pubget Overpricing