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10.1186/s12967-020-02433-6 http://scihub22266oqcxt.onion/10.1186/s12967-020-02433-6 32600410!7322393!32600410     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32600410&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       J+Transl+Med 2020 ; 18 (1): 261 Nephropedia Template TP {{tp|p=32600410|t=2020. Boning up: amino-bisphophonates as immunostimulants and endosomal disruptors of dendritic cell in SARS-CoV-2 infection |pdf=|usr=}}{{32600410}} gab.com Text Boning up: amino-bisphophonates as immunostimulants and endosomal disruptors of dendritic cell in SARS-CoV-2 infection JO: J Transl Med http://www.kidney.de/pget.php?&tw=1&pmid=32600410 #FOAvip Amino-bisphosphonates such as zoledronic acid (ZA) can possibly ameliorate or prevent severe COVID-19 disease by at least three distinct mechanisms: (1) as immunostimulants which could boost gammadelta T cell expansion, important in the acute response in the lung; (2) as DC modulators, limiting their ability to only partially activate T cells; and (3) as prenylation inhibitors of small GTPases in the endosomal pathway of the DC to prevent expulsion of lysosomes containing SARS-CoV-2 virions. Use of ZA or other amino-bisphosphonates as modulators of COVID-19 disease should be considered. Twit Text FOAVip Boning up: amino-bisphophonates as immunostimulants and endosomal disruptors of dendritic cell in SARS-CoV-2 infection ????J Transl Med http://www.kidney.de/pget.php?&tw=1&pmid=32600410 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32600410 #FOAvip English Wikipedia <ref>{{Cite pmid|32600410}}</ref> Boning up: amino-bisphophonates as immunostimulants and endosomal disruptors of dendritic cell in SARS-CoV-2 infection #MMPMID32600410 Brufsky A; Marti JLG; Nasrazadani A; Lotze MT J Transl Med 2020[Jun]; 18 (1): 261 PMID32600410show ga Amino-bisphosphonates such as zoledronic acid (ZA) can possibly ameliorate or prevent severe COVID-19 disease by at least three distinct mechanisms: (1) as immunostimulants which could boost gammadelta T cell expansion, important in the acute response in the lung; (2) as DC modulators, limiting their ability to only partially activate T cells; and (3) as prenylation inhibitors of small GTPases in the endosomal pathway of the DC to prevent expulsion of lysosomes containing SARS-CoV-2 virions. Use of ZA or other amino-bisphosphonates as modulators of COVID-19 disease should be considered. |Animals[MESH] |Betacoronavirus/*physiology[MESH] |COVID-19[MESH] |Coronavirus Infections/*immunology/*virology[MESH] |Dendritic Cells/drug effects/*virology[MESH] |Diphosphonates/*therapeutic use[MESH] |Endosomes/drug effects/*metabolism[MESH] |Humans[MESH] |Immunologic Factors/*pharmacology[MESH] |Pandemics[MESH] |Pneumonia, Viral/*immunology/*virology[MESH]Boning up: amino-bisphophonates as immunostimulants and endosomal disr(epmc).pdf DeepDyve Pubget Overpricing