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10.1016/j.ijbiomac.2020.06.228 http://scihub22266oqcxt.onion/10.1016/j.ijbiomac.2020.06.228 32599245!7319641!32599245     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Biol+Macromol 2020 ; 163 (ä): 1-8 Nephropedia Template TP {{tp|p=32599245|t=2020. Targeting hub genes and pathways of innate immune response in COVID-19: A network biology perspective |pdf=|usr=}}{{32599245}} gab.com Text Targeting hub genes and pathways of innate immune response in COVID-19: A network biology perspective JO: Int J Biol Macromol http://www.kidney.de/pget.php?&tw=1&pmid=32599245 #FOAvip The current pandemic of 2019 novel coronavirus disease (COVID-19) caused by a novel virus strain, 2019-nCoV/SARS-CoV-2 have posed a serious threat to global public health and economy. It is largely unknown how the human immune system responds to this infection. A better understanding of the immune response to SARS-CoV-2 will be important to develop therapeutics against COVID-19. Here, we have used transcriptomic profile of human alveolar adenocarcinoma cells (A549) infected with SARS-CoV-2 and employed a network biology approach to generate human-virus interactome. Network topological analysis discovers 15 SARS-CoV-2 targets, which belongs to a subset of interferon (IFN) stimulated genes (ISGs). These ISGs (IFIT1, IFITM1, IRF7, ISG15, MX1, and OAS2) can be considered as potential candidates for drug targets in the treatments of COVID-19. We have identified significant interaction between ISGs and TLR3 agonists, like poly I: C, and imiquimod, and suggests that TLR3 agonists can be considered as a potential drug for drug repurposing in COVID-19. Our network centric analysis suggests that moderating the innate immune response is a valuable approach to target COVID-19. Twit Text FOAVip Targeting hub genes and pathways of innate immune response in COVID-19: A network biology perspective ????Int J Biol Macromol http://www.kidney.de/pget.php?&tw=1&pmid=32599245 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32599245 #FOAvip English Wikipedia <ref>{{Cite pmid|32599245}}</ref> Targeting hub genes and pathways of innate immune response in COVID-19: A network biology perspective #MMPMID32599245 Prasad K; Khatoon F; Rashid S; Ali N; AlAsmari AF; Ahmed MZ; Alqahtani AS; Alqahtani MS; Kumar V Int J Biol Macromol 2020[Nov]; 163 (ä): 1-8 PMID32599245show ga The current pandemic of 2019 novel coronavirus disease (COVID-19) caused by a novel virus strain, 2019-nCoV/SARS-CoV-2 have posed a serious threat to global public health and economy. It is largely unknown how the human immune system responds to this infection. A better understanding of the immune response to SARS-CoV-2 will be important to develop therapeutics against COVID-19. Here, we have used transcriptomic profile of human alveolar adenocarcinoma cells (A549) infected with SARS-CoV-2 and employed a network biology approach to generate human-virus interactome. Network topological analysis discovers 15 SARS-CoV-2 targets, which belongs to a subset of interferon (IFN) stimulated genes (ISGs). These ISGs (IFIT1, IFITM1, IRF7, ISG15, MX1, and OAS2) can be considered as potential candidates for drug targets in the treatments of COVID-19. We have identified significant interaction between ISGs and TLR3 agonists, like poly I: C, and imiquimod, and suggests that TLR3 agonists can be considered as a potential drug for drug repurposing in COVID-19. Our network centric analysis suggests that moderating the innate immune response is a valuable approach to target COVID-19. |A549 Cells[MESH] |Antiviral Agents/pharmacology[MESH] |Betacoronavirus/*genetics/immunology[MESH] |COVID-19[MESH] |Coronavirus Infections/*genetics/immunology/virology[MESH] |Drug Repositioning[MESH] |ELAV-Like Protein 2/*genetics/immunology/*metabolism[MESH] |Gene Regulatory Networks[MESH] |Humans[MESH] |Immunity, Innate[MESH] |Interferon-gamma/immunology/pharmacology[MESH] |Pandemics[MESH] |Pneumonia, Viral/*genetics/immunology/virology[MESH] |Protein Interaction Maps/genetics[MESH] |SARS-CoV-2[MESH] |Signal Transduction[MESH]Targeting hub genes and pathways of innate immune response in COVID-19(epmc).pdf DeepDyve Pubget Overpricing