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10.1016/j.freeradbiomed.2020.06.032 http://scihub22266oqcxt.onion/10.1016/j.freeradbiomed.2020.06.032 32598985!7319625!32598985     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Free+Radic+Biol+Med 2020 ; 156 (ä): 107-112 Nephropedia Template TP {{tp|p=32598985|t=2020. Potential therapeutic use of ebselen for COVID-19 and other respiratory viral infections |pdf=|usr=}}{{32598985}} gab.com Text Potential therapeutic use of ebselen for COVID-19 and other respiratory viral infections JO: Free Radic Biol Med http://www.kidney.de/pget.php?&tw=1&pmid=32598985 #FOAvip Ebselen is an organoselenium compound exhibiting hydroperoxide- and peroxynitrite-reducing activity, acting as a glutathione peroxidase and peroxiredoxin enzyme mimetic. Ebselen reacts with a multitude of protein thiols, forming a selenosulfide bond, which results in pleiotropic effects of antiviral, antibacterial and anti-inflammatory nature. The main protease (M(pro)) of the corona virus SARS-CoV-2 is a potential drug target, and a screen with over 10,000 compounds identified ebselen as a particularly promising inhibitor of M(pro) (Jin, Z. et al. (2020) Nature 582, 289-293). We discuss here the reaction of ebselen with cysteine proteases, the role of ebselen in infections with viruses and with other microorganisms. We also discuss effects of ebselen in lung inflammation. In further research on the inhibition of M(pro) in SARS-CoV-2, ebselen can serve as a promising lead compound, if the inhibitory effect is confirmed in intact cells in vivo. Independently of this action, potential beneficial effects of ebselen in COVID-19 are ascribed to a number of targets critical to pathogenesis, such as attenuation of inflammatory oxidants and cytokines. Twit Text FOAVip Potential therapeutic use of ebselen for COVID-19 and other respiratory viral infections ????Free Radic Biol Med http://www.kidney.de/pget.php?&tw=1&pmid=32598985 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32598985 #FOAvip English Wikipedia <ref>{{Cite pmid|32598985}}</ref> Potential therapeutic use of ebselen for COVID-19 and other respiratory viral infections #MMPMID32598985 Sies H; Parnham MJ Free Radic Biol Med 2020[Aug]; 156 (ä): 107-112 PMID32598985show ga Ebselen is an organoselenium compound exhibiting hydroperoxide- and peroxynitrite-reducing activity, acting as a glutathione peroxidase and peroxiredoxin enzyme mimetic. Ebselen reacts with a multitude of protein thiols, forming a selenosulfide bond, which results in pleiotropic effects of antiviral, antibacterial and anti-inflammatory nature. The main protease (M(pro)) of the corona virus SARS-CoV-2 is a potential drug target, and a screen with over 10,000 compounds identified ebselen as a particularly promising inhibitor of M(pro) (Jin, Z. et al. (2020) Nature 582, 289-293). We discuss here the reaction of ebselen with cysteine proteases, the role of ebselen in infections with viruses and with other microorganisms. We also discuss effects of ebselen in lung inflammation. In further research on the inhibition of M(pro) in SARS-CoV-2, ebselen can serve as a promising lead compound, if the inhibitory effect is confirmed in intact cells in vivo. Independently of this action, potential beneficial effects of ebselen in COVID-19 are ascribed to a number of targets critical to pathogenesis, such as attenuation of inflammatory oxidants and cytokines. |*Pandemics[MESH] |Anti-Inflammatory Agents, Non-Steroidal/therapeutic use[MESH] |Antioxidants/*therapeutic use[MESH] |Antiviral Agents/*therapeutic use[MESH] |Azoles/*therapeutic use[MESH] |Betacoronavirus/*drug effects/enzymology/pathogenicity[MESH] |Binding Sites[MESH] |COVID-19[MESH] |Coronavirus 3C Proteases[MESH] |Coronavirus Infections/*drug therapy/epidemiology/metabolism/virology[MESH] |Cysteine Endopeptidases/chemistry/metabolism[MESH] |Host-Pathogen Interactions/drug effects/genetics[MESH] |Humans[MESH] |Isoindoles[MESH] |Lung/drug effects/metabolism/pathology/virology[MESH] |Models, Molecular[MESH] |Organoselenium Compounds/*therapeutic use[MESH] |Oxidative Stress/drug effects[MESH] |Pneumonia, Viral/*drug therapy/epidemiology/metabolism/virology[MESH] |Protease Inhibitors/therapeutic use[MESH] |Protein Binding[MESH] |Protein Structure, Secondary[MESH] |Reactive Oxygen Species/antagonists & inhibitors/metabolism[MESH] |SARS-CoV-2[MESH]Potential therapeutic use of ebselen for COVID-19 and other respirator(epmc).pdf DeepDyve Pubget Overpricing