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10.1182/blood.2020007008 http://scihub22266oqcxt.onion/10.1182/blood.2020007008 32597954!7472714!32597954     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Blood 2020 ; 136 (10): 1169-1179 Nephropedia Template TP {{tp|p=32597954|t=2020. Neutrophil extracellular traps contribute to immunothrombosis in COVID-19 acute respiratory distress syndrome |pdf=|usr=}}{{32597954}} gab.com Text Neutrophil extracellular traps contribute to immunothrombosis in COVID-19 acute respiratory distress syndrome JO: Blood http://www.kidney.de/pget.php?&tw=1&pmid=32597954 #FOAvip COVID-19 affects millions of patients worldwide, with clinical presentation ranging from isolated thrombosis to acute respiratory distress syndrome (ARDS) requiring ventilator support. Neutrophil extracellular traps (NETs) originate from decondensed chromatin released to immobilize pathogens, and they can trigger immunothrombosis. We studied the connection between NETs and COVID-19 severity and progression. We conducted a prospective cohort study of COVID-19 patients (n = 33) and age- and sex-matched controls (n = 17). We measured plasma myeloperoxidase (MPO)-DNA complexes (NETs), platelet factor 4, RANTES, and selected cytokines. Three COVID-19 lung autopsies were examined for NETs and platelet involvement. We assessed NET formation ex vivo in COVID-19 neutrophils and in healthy neutrophils incubated with COVID-19 plasma. We also tested the ability of neonatal NET-inhibitory factor (nNIF) to block NET formation induced by COVID-19 plasma. Plasma MPO-DNA complexes increased in COVID-19, with intubation (P < .0001) and death (P < .0005) as outcome. Illness severity correlated directly with plasma MPO-DNA complexes (P = .0360), whereas Pao2/fraction of inspired oxygen correlated inversely (P = .0340). Soluble and cellular factors triggering NETs were significantly increased in COVID-19, and pulmonary autopsies confirmed NET-containing microthrombi with neutrophil-platelet infiltration. Finally, COVID-19 neutrophils ex vivo displayed excessive NETs at baseline, and COVID-19 plasma triggered NET formation, which was blocked by nNIF. Thus, NETs triggering immunothrombosis may, in part, explain the prothrombotic clinical presentations in COVID-19, and NETs may represent targets for therapeutic intervention. Twit Text FOAVip Neutrophil extracellular traps contribute to immunothrombosis in COVID-19 acute respiratory distress syndrome ????Blood http://www.kidney.de/pget.php?&tw=1&pmid=32597954 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32597954 #FOAvip English Wikipedia <ref>{{Cite pmid|32597954}}</ref> Neutrophil extracellular traps contribute to immunothrombosis in COVID-19 acute respiratory distress syndrome #MMPMID32597954 Middleton EA; He XY; Denorme F; Campbell RA; Ng D; Salvatore SP; Mostyka M; Baxter-Stoltzfus A; Borczuk AC; Loda M; Cody MJ; Manne BK; Portier I; Harris ES; Petrey AC; Beswick EJ; Caulin AF; Iovino A; Abegglen LM; Weyrich AS; Rondina MT; Egeblad M; Schiffman JD; Yost CC Blood 2020[Sep]; 136 (10): 1169-1179 PMID32597954show ga COVID-19 affects millions of patients worldwide, with clinical presentation ranging from isolated thrombosis to acute respiratory distress syndrome (ARDS) requiring ventilator support. Neutrophil extracellular traps (NETs) originate from decondensed chromatin released to immobilize pathogens, and they can trigger immunothrombosis. We studied the connection between NETs and COVID-19 severity and progression. We conducted a prospective cohort study of COVID-19 patients (n = 33) and age- and sex-matched controls (n = 17). We measured plasma myeloperoxidase (MPO)-DNA complexes (NETs), platelet factor 4, RANTES, and selected cytokines. Three COVID-19 lung autopsies were examined for NETs and platelet involvement. We assessed NET formation ex vivo in COVID-19 neutrophils and in healthy neutrophils incubated with COVID-19 plasma. We also tested the ability of neonatal NET-inhibitory factor (nNIF) to block NET formation induced by COVID-19 plasma. Plasma MPO-DNA complexes increased in COVID-19, with intubation (P < .0001) and death (P < .0005) as outcome. Illness severity correlated directly with plasma MPO-DNA complexes (P = .0360), whereas Pao2/fraction of inspired oxygen correlated inversely (P = .0340). Soluble and cellular factors triggering NETs were significantly increased in COVID-19, and pulmonary autopsies confirmed NET-containing microthrombi with neutrophil-platelet infiltration. Finally, COVID-19 neutrophils ex vivo displayed excessive NETs at baseline, and COVID-19 plasma triggered NET formation, which was blocked by nNIF. Thus, NETs triggering immunothrombosis may, in part, explain the prothrombotic clinical presentations in COVID-19, and NETs may represent targets for therapeutic intervention. |Adult[MESH] |Aged[MESH] |Betacoronavirus/immunology[MESH] |Blood Platelets/immunology/pathology[MESH] |Blood Proteins/immunology[MESH] |COVID-19[MESH] |Coronavirus Infections/*complications/immunology/pathology[MESH] |Extracellular Traps/*immunology[MESH] |Female[MESH] |Humans[MESH] |Male[MESH] |Middle Aged[MESH] |Neutrophil Infiltration[MESH] |Neutrophils/*immunology/pathology[MESH] |Pandemics[MESH] |Peroxidase/immunology[MESH] |Pneumonia, Viral/*complications/immunology/pathology[MESH] |Prospective Studies[MESH] |SARS-CoV-2[MESH]Neutrophil extracellular traps contribute to immunothrombosis in COVID(epmc).pdf DeepDyve Pubget Overpricing