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10.1126/sciadv.abb5813 http://scihub22266oqcxt.onion/10.1126/sciadv.abb5813 32596474!7299625!32596474     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\32596474.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Adv 2020 ; 6 (25): eabb5813 Nephropedia Template TP {{tp|p=32596474|t=2020. Evidence for host-dependent RNA editing in the transcriptome of SARS-CoV-2 |pdf=|usr=}}{{32596474}} gab.com Text Evidence for host-dependent RNA editing in the transcriptome of SARS-CoV-2 JO: Sci Adv http://www.kidney.de/pget.php?&tw=1&pmid=32596474 #FOAvip The COVID-19 outbreak has become a global health risk, and understanding the response of the host to the SARS-CoV-2 virus will help to combat the disease. RNA editing by host deaminases is an innate restriction process to counter virus infection, but it is not yet known whether this process operates against coronaviruses. Here, we analyze RNA sequences from bronchoalveolar lavage fluids obtained from coronavirus-infected patients. We identify nucleotide changes that may be signatures of RNA editing: adenosine-to-inosine changes from ADAR deaminases and cytosine-to-uracil changes from APOBEC deaminases. Mutational analysis of genomes from different strains of Coronaviridae from human hosts reveals mutational patterns consistent with those observed in the transcriptomic data. However, the reduced ADAR signature in these data raises the possibility that ADARs might be more effective than APOBECs in restricting viral propagation. Our results thus suggest that both APOBECs and ADARs are involved in coronavirus genome editing, a process that may shape the fate of both virus and patient. Twit Text FOAVip Evidence for host-dependent RNA editing in the transcriptome of SARS-CoV-2 ????Sci Adv http://www.kidney.de/pget.php?&tw=1&pmid=32596474 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32596474 #FOAvip English Wikipedia <ref>{{Cite pmid|32596474}}</ref> Evidence for host-dependent RNA editing in the transcriptome of SARS-CoV-2 #MMPMID32596474 Di Giorgio S; Martignano F; Torcia MG; Mattiuz G; Conticello SG Sci Adv 2020[Jun]; 6 (25): eabb5813 PMID32596474show ga The COVID-19 outbreak has become a global health risk, and understanding the response of the host to the SARS-CoV-2 virus will help to combat the disease. RNA editing by host deaminases is an innate restriction process to counter virus infection, but it is not yet known whether this process operates against coronaviruses. Here, we analyze RNA sequences from bronchoalveolar lavage fluids obtained from coronavirus-infected patients. We identify nucleotide changes that may be signatures of RNA editing: adenosine-to-inosine changes from ADAR deaminases and cytosine-to-uracil changes from APOBEC deaminases. Mutational analysis of genomes from different strains of Coronaviridae from human hosts reveals mutational patterns consistent with those observed in the transcriptomic data. However, the reduced ADAR signature in these data raises the possibility that ADARs might be more effective than APOBECs in restricting viral propagation. Our results thus suggest that both APOBECs and ADARs are involved in coronavirus genome editing, a process that may shape the fate of both virus and patient. |*Transcriptome[MESH] |APOBEC Deaminases/genetics/metabolism[MESH] |Adenosine Deaminase/genetics/metabolism[MESH] |Base Sequence/genetics[MESH] |Betacoronavirus/*genetics/*metabolism[MESH] |Bronchoalveolar Lavage Fluid/virology[MESH] |COVID-19[MESH] |Coronavirus Infections/*genetics/virology[MESH] |Genome, Viral/genetics[MESH] |Host-Pathogen Interactions/*genetics[MESH] |Humans[MESH] |Mutation Rate[MESH] |Nucleotides/genetics/metabolism[MESH] |Pandemics[MESH] |Pneumonia, Viral/*genetics/virology[MESH] |RNA Editing/*genetics[MESH] |RNA, Viral/genetics[MESH] |SARS-CoV-2[MESH]Evidence for host-dependent RNA editing in the transcriptome of SARS-C(epmc).pdf DeepDyve Pubget Overpricing