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  • Sars-CoV-2 Envelope and Membrane Proteins: Structural Differences Linked to Virus Characteristics? #MMPMID32596311
  • Bianchi M; Benvenuto D; Giovanetti M; Angeletti S; Ciccozzi M; Pascarella S
  • Biomed Res Int 2020[]; 2020 (ä): 4389089 PMID32596311show ga
  • The Coronavirus Disease 2019 (COVID-19) is a new viral infection caused by the severe acute respiratory coronavirus 2 (SARS-CoV-2). Genomic analyses have revealed that SARS-CoV-2 is related to Pangolin and Bat coronaviruses. In this report, a structural comparison between the Sars-CoV-2 Envelope and Membrane proteins from different human isolates with homologous proteins from closely related viruses is described. The analyses here reported show the high structural similarity of Envelope and Membrane proteins to the counterparts from Pangolin and Bat coronavirus isolates. However, the comparisons have also highlighted structural differences specific of Sars-CoV-2 proteins which may be correlated to the cross-species transmission and/or to the properties of the virus. Structural modelling has been applied to map the variant sites onto the predicted three-dimensional structure of the Envelope and Membrane proteins.
  • |Alphacoronavirus/chemistry/classification/genetics[MESH]
  • |Amino Acid Sequence[MESH]
  • |Animals[MESH]
  • |Betacoronavirus/*chemistry/classification/genetics[MESH]
  • |COVID-19[MESH]
  • |Chiroptera/virology[MESH]
  • |Coronaviridae/chemistry/classification/genetics[MESH]
  • |Coronavirus Envelope Proteins[MESH]
  • |Coronavirus Infections/*virology[MESH]
  • |Eutheria/virology[MESH]
  • |Humans[MESH]
  • |Models, Molecular[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*virology[MESH]
  • |Protein Conformation[MESH]
  • |SARS-CoV-2[MESH]
  • |Sequence Homology, Amino Acid[MESH]
  • |Species Specificity[MESH]
  • |Structural Homology, Protein[MESH]
  • |Viral Envelope Proteins/*chemistry/genetics[MESH]
  • |Viral Matrix Proteins/*chemistry/genetics[MESH]

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  • suck abstract from ncbi

    4389089 ä.2020 2020