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10.3389/fimmu.2020.01372 http://scihub22266oqcxt.onion/10.3389/fimmu.2020.01372 32595654!7301886!32595654     free     free     free Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 259.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 259.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Immunol 2020 ; 11 (ä): 1372 Nephropedia Template TP {{tp|p=32595654|t=2020. Interferon-Induced Transmembrane Protein (IFITM3) Is Upregulated Explicitly in SARS-CoV-2 Infected Lung Epithelial Cells |pdf=|usr=}}{{32595654}} gab.com Text Interferon-Induced Transmembrane Protein (IFITM3) Is Upregulated Explicitly in SARS-CoV-2 Infected Lung Epithelial Cells JO: Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=32595654 #FOAvip Current guidelines for COVID-19 management recommend the utilization of various repurposed drugs. Despite ongoing research toward the development of a vaccine against SARS-CoV-2, such a vaccine will not be available in time to contribute to the containment of the ongoing pandemic. Therefore, there is an urgent need to develop a framework for the rapid identification of novel targets for diagnostic and therapeutic interventions. We analyzed publicly available transcriptomic datasets of SARS-CoV infected humans and mammals to identify consistent differentially expressed genes then validated in SARS-CoV-2 infected epithelial cells transcriptomic datasets. Comprehensive toxicogenomic analysis of the identified genes to identify possible interactions with clinically proven drugs was carried out. We identified IFITM3 as an early upregulated gene, and valproic acid was found to enhance its mRNA expression as well as induce its antiviral action. These findings indicate that analysis of publicly available transcriptomic and toxicogenomic data represents a rapid approach for the identification of novel targets and molecules that can modify the action of such targets during the early phases of emerging infections like COVID-19. Twit Text FOAVip Interferon-Induced Transmembrane Protein (IFITM3) Is Upregulated Explicitly in SARS-CoV-2 Infected Lung Epithelial Cells ????Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=32595654 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32595654 #FOAvip English Wikipedia <ref>{{Cite pmid|32595654}}</ref> Interferon-Induced Transmembrane Protein (IFITM3) Is Upregulated Explicitly in SARS-CoV-2 Infected Lung Epithelial Cells #MMPMID32595654 Hachim MY; Al Heialy S; Hachim IY; Halwani R; Senok AC; Maghazachi AA; Hamid Q Front Immunol 2020[]; 11 (ä): 1372 PMID32595654show ga Current guidelines for COVID-19 management recommend the utilization of various repurposed drugs. Despite ongoing research toward the development of a vaccine against SARS-CoV-2, such a vaccine will not be available in time to contribute to the containment of the ongoing pandemic. Therefore, there is an urgent need to develop a framework for the rapid identification of novel targets for diagnostic and therapeutic interventions. We analyzed publicly available transcriptomic datasets of SARS-CoV infected humans and mammals to identify consistent differentially expressed genes then validated in SARS-CoV-2 infected epithelial cells transcriptomic datasets. Comprehensive toxicogenomic analysis of the identified genes to identify possible interactions with clinically proven drugs was carried out. We identified IFITM3 as an early upregulated gene, and valproic acid was found to enhance its mRNA expression as well as induce its antiviral action. These findings indicate that analysis of publicly available transcriptomic and toxicogenomic data represents a rapid approach for the identification of novel targets and molecules that can modify the action of such targets during the early phases of emerging infections like COVID-19. |*Gene Expression Profiling[MESH] |2',5'-Oligoadenylate Synthetase/genetics[MESH] |Animals[MESH] |Antiviral Agents/pharmacology[MESH] |Betacoronavirus/physiology[MESH] |COVID-19[MESH] |Coronavirus Infections/*genetics/*immunology[MESH] |Disease Models, Animal[MESH] |Ferrets[MESH] |Gene Expression Regulation/drug effects[MESH] |Humans[MESH] |Immunity, Innate[MESH] |Lung[MESH] |Macaca fascicularis[MESH] |Membrane Proteins/*genetics[MESH] |Mice[MESH] |Myxovirus Resistance Proteins/genetics[MESH] |Pandemics[MESH] |Pneumonia, Viral/*genetics/*immunology[MESH] |RNA-Binding Proteins/*genetics[MESH] |SARS-CoV-2[MESH] |Species Specificity[MESH] |Up-Regulation/drug effects[MESH]Interferon-Induced Transmembrane Protein (IFITM3) Is Upregulated Expli(epmc).pdf DeepDyve Pubget Overpricing