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10.3906/biy-2005-91

http://scihub22266oqcxt.onion/10.3906/biy-2005-91
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32595357!7314503!32595357
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suck abstract from ncbi


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pmid32595357      Turk+J+Biol 2020 ; 44 (3): 203-214
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  • SARS-CoV-2 neutralizing antibody development strategies #MMPMID32595357
  • BalcioGlu BK; DenIzcI OncU M; OztUrk HU; YUcel F; Kaya F; Serhatli M; UlbeGI Polat H; TekIn S; OzdemIr Bahadir A
  • Turk J Biol 2020[]; 44 (3): 203-214 PMID32595357show ga
  • In December 2019 a novel coronavirus was detected in Wuhan City of Hubei Province-China. Owing to a high rate of transmission from human to human, the new virus called SARS-CoV-2 differed from others by its unexpectedly rapid spread. The World Health Organization (WHO) described the most recent coronavirus epidemic as a global pandemic in March 2020. The virus spread triggered a health crisis (the COVID-19 disease) within three months, with socioeconomic implications. No approved targeted-therapies are available for COVID-19, yet. However, it is foreseen that antibody-based treatments may provide an immediate cure for patients. Current neutralizing antibody development studies primarily target the S protein among the structural elements of SARS-CoV-2, which mediates the cell entry of the virus through the angiotensin converting enzyme 2 (ACE2) receptor of host cells. This review aims to provide some of the neutralizing antibody development strategies for SARS-CoV-2 and in vitro and in vivo neutralization assays.
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