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10.1016/j.acuro.2020.04.002

http://scihub22266oqcxt.onion/10.1016/j.acuro.2020.04.002
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32595091!ä!32595091

suck abstract from ncbi


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pmid32595091      Actas+Urol+Esp+(Engl+Ed) 2020 ; 44 (7): 497-504
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  • Influencia del tabaquismo en la resistencia bacteriana despues de la profilaxis frente a infecciones urinarias recurrentes con antibiotico o con vacuna #MMPMID32595091
  • Lorenzo-Gomez MF; Santos-Antunes MT; Nieto-Huertos A; Lorenzo-Gomez A; Marquez-Sanchez MT; Flores-Fraile MC; Valverde-Martinez LS; Gonzalez-Casado I; Garcia-Cenador MB; Miron-Canelo JA; Padilla-Fernandez B
  • Actas Urol Esp (Engl Ed) 2020[Sep]; 44 (7): 497-504 PMID32595091show ga
  • INTRODUCTION: The influence of tobacco on the microbiological spectrum, resistance-sensitivity pattern and evolution in patients with recurrent urinary tract infections (RUTI) is analyzed. Evaluation of the effect of polyvalent bacterial vaccine on the prevention of RUTI and smoking status. MATERIAL AND METHODS: Retrospective multicenter study of 855 women with RUTI receiving suppressive antibiotic treatment or bacterial vaccine between 2009 and 2013. Group A (GA): Antibiotic (n=495); Subgroups: GA1 non-smoker (n=417), GA2 smoker (n=78). Group B (GB): Vaccine (n=360); Subgroups: GB1 non-smoker (n=263), GB2 smoker (n=97). VARIABLES: Age, pre-treatment UTI, disease-free time (DFT), microbial species, sensitivity and resistance. Follow-up at 3, 6 and 12 months with culture and SF-36 questionnaire. RESULTS: Mean age 56.51 years (18-75), similar between groups (P=.2257). No difference in the number of pretreatment UTIs (P=.1329) or in the distribution of the bacterial spectrum (P=.7471). DFT was higher in subgroups B compared with A. Urine cultures in GA1: E. coli 62.71% with 8.10% resistance (33% quinolones; 33% cotrimoxazole; 33% quinolones + cotrimoxazole); in GA2 E. coli 61.53% with 75% resistance (16.66% quinolones; 33.33% quinolones + cotrimoxazole; 16.66% amoxicillin-clavulanate; 16.66% erythromycin + phosphomycin + clindamycin) (P=.0133). There were no differences between patients of GA treated with cotrimoxazole and nitrofurantoin (P=.8724). Urine cultures in GB1: E. coli 47.36% with 22.22% resistance (5.55% ciprofloxacin; 5.55% cotrimoxazole; 5.55% ciprofloxacin + cotrimoxazole; 5.55% amoxicillin/clavulanic acid). In GB2 E. coli 70.02% with 61.90% resistances (30.76% quinolones; 30.76% cotrimoxazole; 30.76% quinolones + cotrimoxazole; 17.69% amoxicillin-clavulanic acid) (P=.0144). CONCLUSIONS: The development of bacterial resistance is more frequent among women with smoking habits and recurrent urinary infections. This could influence a worse response to preventive treatments, either with antibiotics or vaccines.
  • |*Antibiotic Prophylaxis[MESH]
  • |*Bacterial Vaccines[MESH]
  • |*Drug Resistance, Bacterial[MESH]
  • |Adolescent[MESH]
  • |Adult[MESH]
  • |Aged[MESH]
  • |Bacterial Infections/*drug therapy/*prevention & control[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Middle Aged[MESH]
  • |Recurrence[MESH]
  • |Retrospective Studies[MESH]
  • |Smoking/*adverse effects[MESH]
  • |Urinary Tract Infections/*drug therapy/*microbiology[MESH]


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