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10.1016/j.numecd.2020.05.013

http://scihub22266oqcxt.onion/10.1016/j.numecd.2020.05.013
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suck abstract from ncbi


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pmid32595085      Nutr+Metab+Cardiovasc+Dis 2020 ; 30 (8): 1227-1235
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  • Covid-19 and cardiovascular risk: Susceptibility to infection to SARS-CoV-2, severity and prognosis of Covid-19 and blockade of the renin-angiotensin-aldosterone system An evidence-based viewpoint #MMPMID32595085
  • Cappuccio FP; Siani A
  • Nutr Metab Cardiovasc Dis 2020[Jul]; 30 (8): 1227-1235 PMID32595085show ga
  • The presence of cardiovascular co-morbidities and the known effects of coronaviruses on the cardiovascular system have called attention to the potential implications for patients with cardiovascular risk factors. This evidence-based viewpoint will address two questions: (a) are individuals with underlying cardiovascular risk factors (e.g. high blood pressure or diabetes) or overt disease (e.g. coronary heart disease, heart failure, kidney disease) more likely to develop severe Covid-19 and to die than those without underlying conditions? (b) does the regular use of angiotensin-converting enzyme inhibitors (ACE-i) or angiotensin-receptor blockers (ARB) make patients more likely to get infected and to die of Covid-19? With a necessary cautionary note that the evidence around the links between Covid-19 and cardiovascular disease is accruing at a fast pace, to date we can conclude that: (a) the greater susceptibility of individuals with underlying cardiovascular conditions to develop more severe Covid-19 with higher mortality rate is likely to be confounded, in part, by age and the type of co-morbidities. Patients with heart failure or chronic kidney disease might show an excess risk; (b) neither ACE-i nor ARB are associated with greater risk of SARS-Cov2 infection, or severity or risk of death in patients with Covid-19. Patients on these drugs should not stop them, unless under strict medical supervision and with the addition of a suitable replacement medicine.
  • |*Betacoronavirus[MESH]
  • |Aged[MESH]
  • |Angiotensin Receptor Antagonists/therapeutic use[MESH]
  • |Angiotensin-Converting Enzyme Inhibitors/therapeutic use[MESH]
  • |COVID-19[MESH]
  • |Cardiovascular Diseases/*complications[MESH]
  • |Coronavirus Infections/*etiology/mortality[MESH]
  • |Humans[MESH]
  • |Middle Aged[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*etiology/mortality[MESH]
  • |Prognosis[MESH]
  • |Renin-Angiotensin System/physiology[MESH]


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