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10.1002/eji.202048724

http://scihub22266oqcxt.onion/10.1002/eji.202048724
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32592406!7361574!32592406
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suck abstract from ncbi


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pmid32592406      Eur+J+Immunol 2020 ; 50 (9): 1412-1414
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  • Immune response in children with COVID-19 is characterized by lower levels of T-cell activation than infected adults #MMPMID32592406
  • Moratto D; Giacomelli M; Chiarini M; Savare L; Saccani B; Motta M; Timpano S; Poli P; Paghera S; Imberti L; Cannizzo S; Quiros-Roldan E; Marchetti G; Badolato R
  • Eur J Immunol 2020[Sep]; 50 (9): 1412-1414 PMID32592406show ga
  • Study of immunological features of immune response in 14 children (aged from 12 days up to 15 years) and of 10 adults who developed COVID-19 show increased number of activated CD4 and CD8 cells expressing DR and higher plasmatic levels of IL-12 and IL-1beta in adults with COVID-19, but not in children. In addition, plasmatic levels of CCL5/RANTES are higher in children and adults with COVID-19, while CXCL9/MIG was only increased in adults. Higher number of activated T cells and expression of IL-12 and CXCL9 suggest prominent Th1 polarization of immune response against SARS-CoV2 in infected adults as compared with children.
  • |Adolescent[MESH]
  • |CD4-Positive T-Lymphocytes/*immunology[MESH]
  • |CD8-Positive T-Lymphocytes/*immunology[MESH]
  • |COVID-19/*blood/immunology/pathology[MESH]
  • |Chemokine CCL2/blood[MESH]
  • |Chemokine CCL5/blood[MESH]
  • |Chemokine CXCL10/blood[MESH]
  • |Chemokine CXCL9/blood[MESH]
  • |Chemokines/*blood[MESH]
  • |Child[MESH]
  • |Child, Preschool[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Infant[MESH]
  • |Infant, Newborn[MESH]
  • |Interleukin-8/blood[MESH]
  • |Lymphocyte Activation[MESH]
  • |Lymphocyte Count[MESH]
  • |Lymphopenia/pathology[MESH]
  • |Male[MESH]
  • |SARS-CoV-2/*immunology[MESH]


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