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10.1038/s41587-020-0602-4 http://scihub22266oqcxt.onion/10.1038/s41587-020-0602-4 32591762!ä!32591762 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Biotechnol 2020 ; 38 (8): 970-979 Nephropedia Template TP {{tp|p=32591762|t=2020. COVID-19 severity correlates with airway epithelium-immune cell interactions identified by single-cell analysis |pdf=|usr=}}{{32591762}} gab.com Text COVID-19 severity correlates with airway epithelium-immune cell interactions identified by single-cell analysis JO: Nat Biotechnol http://www.kidney.de/pget.php?&tw=1&pmid=32591762 #FOAvip To investigate the immune response and mechanisms associated with severe coronavirus disease 2019 (COVID-19), we performed single-cell RNA sequencing on nasopharyngeal and bronchial samples from 19 clinically well-characterized patients with moderate or critical disease and from five healthy controls. We identified airway epithelial cell types and states vulnerable to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. In patients with COVID-19, epithelial cells showed an average three-fold increase in expression of the SARS-CoV-2 entry receptor ACE2, which correlated with interferon signals by immune cells. Compared to moderate cases, critical cases exhibited stronger interactions between epithelial and immune cells, as indicated by ligand-receptor expression profiles, and activated immune cells, including inflammatory macrophages expressing CCL2, CCL3, CCL20, CXCL1, CXCL3, CXCL10, IL8, IL1B and TNF. The transcriptional differences in critical cases compared to moderate cases likely contribute to clinical observations of heightened inflammatory tissue damage, lung injury and respiratory failure. Our data suggest that pharmacologic inhibition of the CCR1 and/or CCR5 pathways might suppress immune hyperactivation in critical COVID-19. Twit Text FOAVip COVID-19 severity correlates with airway epithelium-immune cell interactions identified by single-cell analysis ????Nat Biotechnol http://www.kidney.de/pget.php?&tw=1&pmid=32591762 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32591762 #FOAvip English Wikipedia <ref>{{Cite pmid|32591762}}</ref> COVID-19 severity correlates with airway epithelium-immune cell interactions identified by single-cell analysis #MMPMID32591762 Chua RL; Lukassen S; Trump S; Hennig BP; Wendisch D; Pott F; Debnath O; Thurmann L; Kurth F; Volker MT; Kazmierski J; Timmermann B; Twardziok S; Schneider S; Machleidt F; Muller-Redetzky H; Maier M; Krannich A; Schmidt S; Balzer F; Liebig J; Loske J; Suttorp N; Eils J; Ishaque N; Liebert UG; von Kalle C; Hocke A; Witzenrath M; Goffinet C; Drosten C; Laudi S; Lehmann I; Conrad C; Sander LE; Eils R Nat Biotechnol 2020[Aug]; 38 (8): 970-979 PMID32591762show ga To investigate the immune response and mechanisms associated with severe coronavirus disease 2019 (COVID-19), we performed single-cell RNA sequencing on nasopharyngeal and bronchial samples from 19 clinically well-characterized patients with moderate or critical disease and from five healthy controls. We identified airway epithelial cell types and states vulnerable to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. In patients with COVID-19, epithelial cells showed an average three-fold increase in expression of the SARS-CoV-2 entry receptor ACE2, which correlated with interferon signals by immune cells. Compared to moderate cases, critical cases exhibited stronger interactions between epithelial and immune cells, as indicated by ligand-receptor expression profiles, and activated immune cells, including inflammatory macrophages expressing CCL2, CCL3, CCL20, CXCL1, CXCL3, CXCL10, IL8, IL1B and TNF. The transcriptional differences in critical cases compared to moderate cases likely contribute to clinical observations of heightened inflammatory tissue damage, lung injury and respiratory failure. Our data suggest that pharmacologic inhibition of the CCR1 and/or CCR5 pathways might suppress immune hyperactivation in critical COVID-19. |*Single-Cell Analysis[MESH] |*Transcriptome[MESH] |Adult[MESH] |Aged[MESH] |Angiotensin-Converting Enzyme 2[MESH] |Bronchoalveolar Lavage Fluid/virology[MESH] |COVID-19[MESH] |Cell Communication[MESH] |Cell Differentiation[MESH] |Coronavirus Infections/*pathology/*physiopathology/virology[MESH] |Epithelial Cells/pathology/virology[MESH] |Female[MESH] |Humans[MESH] |Immune System/pathology[MESH] |Inflammation/immunology/pathology[MESH] |Longitudinal Studies[MESH] |Male[MESH] |Middle Aged[MESH] |Nasopharynx/virology[MESH] |Pandemics[MESH] |Peptidyl-Dipeptidase A/genetics[MESH] |Pneumonia, Viral/*pathology/*physiopathology/virology[MESH] |Respiratory System/immunology/*pathology/virology[MESH]COVID-19 severity correlates with airway epithelium-immune cell intera(epmc).pdf DeepDyve Pubget Overpricing