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10.4049/jimmunol.2000583 http://scihub22266oqcxt.onion/10.4049/jimmunol.2000583 32591393!7566074!32591393     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Immunol 2020 ; 205 (4): 915-922 Nephropedia Template TP {{tp|p=32591393|t=2020. A Potently Neutralizing Antibody Protects Mice against SARS-CoV-2 Infection |pdf=|usr=}}{{32591393}} gab.com Text A Potently Neutralizing Antibody Protects Mice against SARS-CoV-2 Infection JO: J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=32591393 #FOAvip Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for millions of infections and hundreds of thousands of deaths globally. There are no widely available licensed therapeutics against SARS-CoV-2, highlighting an urgent need for effective interventions. The virus enters host cells through binding of a receptor-binding domain within its trimeric spike glycoprotein to human angiotensin-converting enzyme 2. In this article, we describe the generation and characterization of a panel of murine mAbs directed against the receptor-binding domain. One mAb, 2B04, neutralized wild-type SARS-CoV-2 in vitro with remarkable potency (half-maximal inhibitory concentration of <2 ng/ml). In a murine model of SARS-CoV-2 infection, 2B04 protected challenged animals from weight loss, reduced lung viral load, and blocked systemic dissemination. Thus, 2B04 is a promising candidate for an effective antiviral that can be used to prevent SARS-CoV-2 infection. Twit Text FOAVip A Potently Neutralizing Antibody Protects Mice against SARS-CoV-2 Infection ????J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=32591393 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32591393 #FOAvip English Wikipedia <ref>{{Cite pmid|32591393}}</ref> A Potently Neutralizing Antibody Protects Mice against SARS-CoV-2 Infection #MMPMID32591393 Alsoussi WB; Turner JS; Case JB; Zhao H; Schmitz AJ; Zhou JQ; Chen RE; Lei T; Rizk AA; McIntire KM; Winkler ES; Fox JM; Kafai NM; Thackray LB; Hassan AO; Amanat F; Krammer F; Watson CT; Kleinstein SH; Fremont DH; Diamond MS; Ellebedy AH J Immunol 2020[Aug]; 205 (4): 915-922 PMID32591393show ga Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for millions of infections and hundreds of thousands of deaths globally. There are no widely available licensed therapeutics against SARS-CoV-2, highlighting an urgent need for effective interventions. The virus enters host cells through binding of a receptor-binding domain within its trimeric spike glycoprotein to human angiotensin-converting enzyme 2. In this article, we describe the generation and characterization of a panel of murine mAbs directed against the receptor-binding domain. One mAb, 2B04, neutralized wild-type SARS-CoV-2 in vitro with remarkable potency (half-maximal inhibitory concentration of <2 ng/ml). In a murine model of SARS-CoV-2 infection, 2B04 protected challenged animals from weight loss, reduced lung viral load, and blocked systemic dissemination. Thus, 2B04 is a promising candidate for an effective antiviral that can be used to prevent SARS-CoV-2 infection. |Angiotensin-Converting Enzyme 2[MESH] |Animals[MESH] |Antibodies, Monoclonal/immunology/pharmacology/*therapeutic use[MESH] |Antibodies, Neutralizing/immunology/pharmacology/*therapeutic use[MESH] |Antibodies, Viral/immunology/pharmacology/*therapeutic use[MESH] |Betacoronavirus/*drug effects[MESH] |COVID-19[MESH] |Chlorocebus aethiops[MESH] |Coronavirus Infections/*drug therapy/*immunology/virology[MESH] |Disease Models, Animal[MESH] |Epitope Mapping[MESH] |Female[MESH] |HEK293 Cells[MESH] |Humans[MESH] |Immunodominant Epitopes/immunology[MESH] |Mice[MESH] |Mice, Inbred C57BL[MESH] |Pandemics[MESH] |Peptidyl-Dipeptidase A/genetics/metabolism[MESH] |Pneumonia, Viral/*drug therapy/*immunology/virology[MESH] |Protein Interaction Domains and Motifs/genetics/immunology[MESH] |SARS-CoV-2[MESH] |Spike Glycoprotein, Coronavirus/chemistry/metabolism[MESH] |Transfection[MESH]A Potently Neutralizing Antibody Protects Mice against SARS-CoV-2 Infe(epmc).pdf DeepDyve Pubget Overpricing