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10.1016/j.nrl.2020.06.001 http://scihub22266oqcxt.onion/10.1016/j.nrl.2020.06.001 32591152!7836312!32591152     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Neurologia+(Engl+Ed) 2020 ; 35 (6): 357-362 Nephropedia Template TP {{tp|p=32591152|t=2020. Tratamiento inmunosupresor en pulsos en esclerosis multiple durante el desescalado de la epidemia por SARS-CoV-2 Algoritmo de seguridad |pdf=|usr=}}{{32591152}} gab.com Text Tratamiento inmunosupresor en pulsos en esclerosis multiple durante el desescalado de la epidemia por SARS-CoV-2 Algoritmo de seguridad JO: Neurologia (Engl Ed) http://www.kidney.de/pget.php?&tw=1&pmid=32591152 #FOAvip INTRODUCTION: The COVID-19 pandemic is changing approaches to diagnosis, treatment, and care provision in multiple sclerosis (MS). During both the initial and peak phases of the epidemic, the administration of disease-modifying drugs, typically immunosuppressants administered in pulses, was suspended due to the uncertainty about their impact on SARS-CoV-2 infection, mainly in contagious asymptomatic/presymptomatic patients. The purpose of this study is to present a safety algorithm enabling patients to resume pulse immunosuppressive therapy (PIT) during the easing of lockdown measures. METHODS: We developed a safety algorithm based on our clinical experience with MS and the available published evidence; the algorithm assists in the detection of contagious asymptomatic/presymptomatic cases and of patients with mild symptoms of SARS-CoV-2 infection with a view to withdrawing PIT in these patients and preventing new infections at day hospitals. RESULTS: We developed a clinical/microbiological screening algorithm consisting of a symptom checklist, applied during a teleconsultation 48hours before the scheduled session of PIT, and PCR testing for SARS-CoV-2 in nasopharyngeal exudate 24hours before the procedure. CONCLUSION: The application of our safety algorithm presents a favourable risk-benefit ratio despite the fact that the actual proportion of asymptomatic and presymptomatic individuals is unknown. Systematic PCR testing, which provides the highest sensitivity for detecting presymptomatic cases, combined with early detection of symptoms of SARS-CoV-2 infection may reduce infections and improve detection of high-risk patients before they receive PIT. Twit Text FOAVip Tratamiento inmunosupresor en pulsos en esclerosis multiple durante el desescalado de la epidemia por SARS-CoV-2 Algoritmo de seguridad ????Neurologia (Engl Ed) http://www.kidney.de/pget.php?&tw=1&pmid=32591152 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32591152 #FOAvip English Wikipedia <ref>{{Cite pmid|32591152}}</ref> Tratamiento inmunosupresor en pulsos en esclerosis multiple durante el desescalado de la epidemia por SARS-CoV-2 Algoritmo de seguridad #MMPMID32591152 Valero-Lopez G; Carreon-Guarnizo E; Hernandez-Clares R; Iniesta-Martinez F; Jimenez-Veiga J; Moreno-Docon A; Iborra-Bendicho MA; Aznar-Robles E; Hellin-Gil MF; Morales-Ortiz A; Meca-Lallana JE Neurologia (Engl Ed) 2020[Jul]; 35 (6): 357-362 PMID32591152show ga INTRODUCTION: The COVID-19 pandemic is changing approaches to diagnosis, treatment, and care provision in multiple sclerosis (MS). During both the initial and peak phases of the epidemic, the administration of disease-modifying drugs, typically immunosuppressants administered in pulses, was suspended due to the uncertainty about their impact on SARS-CoV-2 infection, mainly in contagious asymptomatic/presymptomatic patients. The purpose of this study is to present a safety algorithm enabling patients to resume pulse immunosuppressive therapy (PIT) during the easing of lockdown measures. METHODS: We developed a safety algorithm based on our clinical experience with MS and the available published evidence; the algorithm assists in the detection of contagious asymptomatic/presymptomatic cases and of patients with mild symptoms of SARS-CoV-2 infection with a view to withdrawing PIT in these patients and preventing new infections at day hospitals. RESULTS: We developed a clinical/microbiological screening algorithm consisting of a symptom checklist, applied during a teleconsultation 48hours before the scheduled session of PIT, and PCR testing for SARS-CoV-2 in nasopharyngeal exudate 24hours before the procedure. CONCLUSION: The application of our safety algorithm presents a favourable risk-benefit ratio despite the fact that the actual proportion of asymptomatic and presymptomatic individuals is unknown. Systematic PCR testing, which provides the highest sensitivity for detecting presymptomatic cases, combined with early detection of symptoms of SARS-CoV-2 infection may reduce infections and improve detection of high-risk patients before they receive PIT. |*Algorithms[MESH] |Ambulatory Care[MESH] |Asymptomatic Diseases[MESH] |Betacoronavirus/*isolation & purification[MESH] |COVID-19[MESH] |COVID-19 Testing[MESH] |Checklist[MESH] |Clinical Laboratory Techniques[MESH] |Contraindications, Drug[MESH] |Coronavirus Infections/diagnosis/*prevention & control[MESH] |Disease Susceptibility[MESH] |Humans[MESH] |Immunocompromised Host[MESH] |Immunosuppressive Agents/*administration & dosage/adverse effects/therapeutic use[MESH] |Mass Screening/methods[MESH] |Multiple Sclerosis/*drug therapy[MESH] |Nasopharynx/virology[MESH] |Pandemics/*prevention & control[MESH] |Pneumonia, Viral/diagnosis/*prevention & control[MESH] |Polymerase Chain Reaction[MESH] |Pulse Therapy, Drug[MESH] |Quarantine[MESH] |Risk Assessment[MESH] |SARS-CoV-2[MESH] |Symptom Assessment[MESH]Tratamiento inmunosupresor en pulsos en esclerosis multiple durante el(epmc).pdf DeepDyve Pubget Overpricing