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10.1177/1040638720937105

http://scihub22266oqcxt.onion/10.1177/1040638720937105
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32589111!7438646!32589111
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suck abstract from ncbi


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pmid32589111      J+Vet+Diagn+Invest 2020 ; 32 (4): 616-620
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  • Persistent infection and pancytopenia associated with ferret systemic coronaviral disease in a domestic ferret #MMPMID32589111
  • Tarbert DK; Bolin LL; Stout AE; Schaefer DMW; Ruby RE; Rodriguez-Ramos Fernandez J; Duhamel GE; Whittaker GR; de Matos R
  • J Vet Diagn Invest 2020[Jul]; 32 (4): 616-620 PMID32589111show ga
  • Ferret systemic coronaviral disease (FSCD) is a well-established cause of mortality in domestic ferrets. We describe herein novel findings in a case of FSCD that was diagnosed and medically managed following virus detection by immunohistochemical (IHC) staining of surgical biopsy samples. Hematologic changes in this ferret suggested spread of the virus to the bone marrow, which was confirmed by IHC staining of a postmortem sample. Genotyping of the virus indicated that the virus grouped with alphacoronaviruses and was most closely related to ferret enteric coronavirus (FRECV) MSU-2. Our clinical case demonstrates that a FRECV MSU-2-like ferret coronavirus associated previously with the enteric pathotype may cause systemic disease, including bone marrow involvement causing persistent pancytopenia.
  • |Alphacoronavirus/*isolation & purification[MESH]
  • |Animals[MESH]
  • |Coronavirus Infections/*veterinary/virology[MESH]
  • |Ferrets/*virology[MESH]


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