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10.4269/ajtmh.20-0473

http://scihub22266oqcxt.onion/10.4269/ajtmh.20-0473
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suck abstract from ncbi


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pmid32588812      Am+J+Trop+Med+Hyg 2020 ; 103 (2): 561-563
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  • Insights into the Use of C-Reactive Protein as a Diagnostic Index of Disease Severity in COVID-19 Infections #MMPMID32588812
  • Potempa LA; Rajab IM; Hart PC; Bordon J; Fernandez-Botran R
  • Am J Trop Med Hyg 2020[Aug]; 103 (2): 561-563 PMID32588812show ga
  • Approximately 20% of patients infected with SARS-CoV-2 (COVID-19) develop potentially life-threatening pathologies involving hyperinflammation, cytokine storm, septic shock complications, coagulation dysfunction, and multiple organ failure. Blood levels of the prototypic acute phase reactant, C-reactive protein (CRP), which is hepatically synthesized and released in response to interleukin-6 stimulation, is markedly elevated in patients with COVID-19. Markedly high CRP levels correlate with poor prognosis for survival. Insights into CRP structure-function relationships have uncovered both pro- and anti-inflammatory isoforms that may be used to monitor the extent of tissue damage associated with COVID-19 pathologies and prognoses. Herein, rationale is given for interpretation of CRP blood levels as a simple, rapid, and cost-effective way to assess disease severity and help guide therapeutic options in COVID-19 patients.
  • |Betacoronavirus[MESH]
  • |C-Reactive Protein/*analysis[MESH]
  • |COVID-19[MESH]
  • |COVID-19 Testing[MESH]
  • |Clinical Laboratory Techniques[MESH]
  • |Coronavirus Infections/blood/*diagnosis[MESH]
  • |Humans[MESH]
  • |Inflammation[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/blood/*diagnosis[MESH]
  • |Prognosis[MESH]
  • |Protein Isoforms/blood[MESH]


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