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10.1177/2050640620931657 http://scihub22266oqcxt.onion/10.1177/2050640620931657 32588791!7435007!32588791     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       United+European+Gastroenterol+J 2020 ; 8 (7): 814-819 Nephropedia Template TP {{tp|p=32588791|t=2020. Patterns of liver injury in COVID-19 - a German case series |pdf=|usr=}}{{32588791}} gab.com Text Patterns of liver injury in COVID-19 - a German case series JO: United European Gastroenterol J http://www.kidney.de/pget.php?&tw=1&pmid=32588791 #FOAvip BACKGROUND: Reports of liver injury in patients with novel coronavirus disease 2019 (COVID-19) are emerging from China and the USA. A wide variety of liver function test abnormalities and few cases of severe liver failure have been reported. No data on the hepatic phenotype from Europe are available at current. METHODS: We report a case series of 44 consecutive patients hospitalized for COVID-19 in Germany. RESULTS: At the time of admission, aspartate aminotransferase greater than the upper limit of normal was present in 70%, while alanine aminotransferase was elevated in 15.8%. Markers of cholestatic liver injury were altered only in a minority of patients. During hospitalization, 31% and 22% experienced increasing aspartate aminotransferase and alanine aminotransferase, respectively, when transaminases were normal at admission. Severe liver injury defined by 3x> upper limit of normal was observed in 9.1% over a mean time of 10.5 days. Importantly, patients exhibited cytotoxicity including lactate dehydrogenase and creatinine kinase elevations, but no signs of relevant liver function impairment. CONCLUSION: In summary, in a case series of hospitalized patients in Germany, cytotoxicity in the absence of severe liver dysfunction at admission and only few cases suggestive of severe liver injury during hospital were observed. Twit Text FOAVip Patterns of liver injury in COVID-19 - a German case series ????United European Gastroenterol J http://www.kidney.de/pget.php?&tw=1&pmid=32588791 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32588791 #FOAvip English Wikipedia <ref>{{Cite pmid|32588791}}</ref> Patterns of liver injury in COVID-19 - a German case series #MMPMID32588791 Schattenberg JM; Labenz C; Worns MA; Menge P; Weinmann A; Galle PR; Sprinzl MF United European Gastroenterol J 2020[Aug]; 8 (7): 814-819 PMID32588791show ga BACKGROUND: Reports of liver injury in patients with novel coronavirus disease 2019 (COVID-19) are emerging from China and the USA. A wide variety of liver function test abnormalities and few cases of severe liver failure have been reported. No data on the hepatic phenotype from Europe are available at current. METHODS: We report a case series of 44 consecutive patients hospitalized for COVID-19 in Germany. RESULTS: At the time of admission, aspartate aminotransferase greater than the upper limit of normal was present in 70%, while alanine aminotransferase was elevated in 15.8%. Markers of cholestatic liver injury were altered only in a minority of patients. During hospitalization, 31% and 22% experienced increasing aspartate aminotransferase and alanine aminotransferase, respectively, when transaminases were normal at admission. Severe liver injury defined by 3x> upper limit of normal was observed in 9.1% over a mean time of 10.5 days. Importantly, patients exhibited cytotoxicity including lactate dehydrogenase and creatinine kinase elevations, but no signs of relevant liver function impairment. CONCLUSION: In summary, in a case series of hospitalized patients in Germany, cytotoxicity in the absence of severe liver dysfunction at admission and only few cases suggestive of severe liver injury during hospital were observed. |Adult[MESH] |Aged[MESH] |Aged, 80 and over[MESH] |Alanine Transaminase/blood[MESH] |Antiviral Agents/*adverse effects[MESH] |Aspartate Aminotransferases/blood[MESH] |Betacoronavirus/*pathogenicity[MESH] |Biomarkers/blood[MESH] |COVID-19[MESH] |COVID-19 Drug Treatment[MESH] |COVID-19 Testing[MESH] |Chemical and Drug Induced Liver Injury/blood/diagnosis/*epidemiology/etiology[MESH] |Clinical Laboratory Techniques/statistics & numerical data[MESH] |Coronavirus Infections/*complications/diagnosis/drug therapy/epidemiology/virology[MESH] |Electronic Health Records/statistics & numerical data[MESH] |Female[MESH] |Germany/epidemiology[MESH] |Humans[MESH] |Liver Failure, Acute/blood/diagnosis/*epidemiology/virology[MESH] |Liver Function Tests/statistics & numerical data[MESH] |Liver/drug effects/virology[MESH] |Male[MESH] |Middle Aged[MESH] |Pandemics[MESH] |Pneumonia, Viral/*complications/drug therapy/epidemiology/virology[MESH] |Retrospective Studies[MESH] |SARS-CoV-2[MESH]Patterns of liver injury in COVID-19 - a German case series (epmc).pdf DeepDyve Pubget Overpricing