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10.1002/cpt.1968

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suck abstract from ncbi


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pmid32588427      Clin+Pharmacol+Ther 2020 ; 108 (5): 1090-1097
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  • QT Interval Prolongation Under Hydroxychloroquine/Azithromycin Association for Inpatients With SARS-CoV-2 Lower Respiratory Tract Infection #MMPMID32588427
  • Bun SS; Taghji P; Courjon J; Squara F; Scarlatti D; Theodore G; Baudouy D; Sartre B; Labbaoui M; Dellamonica J; Doyen D; Marquette CH; Levraut J; Esnault V; Bun SS; Ferrari E
  • Clin Pharmacol Ther 2020[Nov]; 108 (5): 1090-1097 PMID32588427show ga
  • Association between Hydroxychloroquine (HCQ) and Azithromycin (AZT) is under evaluation for patients with lower respiratory tract infection (LRTI) caused by the Severe Acute Respiratory Syndrome (SARS-CoV-2). Both drugs have a known torsadogenic potential, but sparse data are available concerning QT prolongation induced by this association. Our objective was to assess for COVID-19 LRTI variations of QT interval under HCQ/AZT in patients hospitalized, and to compare manual versus automated QT measurements. Before therapy initiation, a baseline 12 lead-ECG was electronically sent to our cardiology department for automated and manual QT analysis (Bazett and Fridericia's correction), repeated 2 days after initiation. According to our institutional protocol (Pasteur University Hospital), HCQ/AZT was initiated only if baseline QTc 4.0 mmol/L. From March 24(th) to April 20(th) 2020, 73 patients were included (mean age 62 +/- 14 years, male 67%). Two patients out of 73 (2.7%) were not eligible for drug initiation (QTc >/= 500 ms). Baseline average automated QTc was 415 +/- 29 ms and lengthened to 438 +/- 40 ms after 48 hours of combined therapy. The treatment had to be stopped because of significant QTc prolongation in two out of 71 patients (2.8%). No drug-induced life-threatening arrhythmia, nor death was observed. Automated QTc measurements revealed accurate in comparison with manual QTc measurements. In this specific population of inpatients with COVID-19 LRTI, HCQ/AZT could not be initiated or had to be interrupted in less than 6% of the cases.
  • |*Azithromycin/administration & dosage/adverse effects/pharmacokinetics[MESH]
  • |*Coronavirus Infections/diagnosis/drug therapy/physiopathology[MESH]
  • |*Drug Monitoring/instrumentation/methods/standards[MESH]
  • |*Hydroxychloroquine/administration & dosage/adverse effects/pharmacokinetics[MESH]
  • |*Long QT Syndrome/chemically induced/diagnosis[MESH]
  • |*Pandemics[MESH]
  • |Anti-Infective Agents/administration & dosage/adverse effects/pharmacokinetics[MESH]
  • |Betacoronavirus/isolation & purification[MESH]
  • |COVID-19[MESH]
  • |COVID-19 Drug Treatment[MESH]
  • |Dimensional Measurement Accuracy[MESH]
  • |Electrocardiography/*methods[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Outcome Assessment, Health Care[MESH]
  • |Pneumonia, Viral/diagnosis/*drug therapy/physiopathology[MESH]
  • |SARS-CoV-2[MESH]


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