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10.1101/2020.06.12.148916 http://scihub22266oqcxt.onion/10.1101/2020.06.12.148916 32587963!7310619!32587963     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\32587963.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       bioRxiv 2020 ; ä (ä): ä Nephropedia Template TP {{tp|p=32587963|t=2020. Single-cell transcriptomic analysis of SARS-CoV-2 reactive CD4 (+) T cells |pdf=|usr=}}{{32587963}} gab.com Text Single-cell transcriptomic analysis of SARS-CoV-2 reactive CD4 (+) T cells JO: bioRxiv http://www.kidney.de/pget.php?&tw=1&pmid=32587963 #FOAvip The contribution of CD4 (+) T cells to protective or pathogenic immune responses to SARS-CoV-2 infection remains unknown. Here, we present large-scale single-cell transcriptomic analysis of viral antigen-reactive CD4 (+) T cells from 32 COVID-19 patients. In patients with severe disease compared to mild disease, we found increased proportions of cytotoxic follicular helper (T (FH) ) cells and cytotoxic T helper cells (CD4-CTLs) responding to SARS-CoV-2, and reduced proportion of SARS-CoV-2 reactive regulatory T cells. Importantly, the CD4-CTLs were highly enriched for the expression of transcripts encoding chemokines that are involved in the recruitment of myeloid cells and dendritic cells to the sites of viral infection. Polyfunctional T helper (T (H) )1 cells and T (H) 17 cell subsets were underrepresented in the repertoire of SARS-CoV-2-reactive CD4 (+) T cells compared to influenza-reactive CD4 (+) T cells. Together, our analyses provide so far unprecedented insights into the gene expression patterns of SARS-CoV-2 reactive CD4 (+) T cells in distinct disease severities. Twit Text FOAVip Single-cell transcriptomic analysis of SARS-CoV-2 reactive CD4 (+) T cells ????bioRxiv http://www.kidney.de/pget.php?&tw=1&pmid=32587963 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32587963 #FOAvip English Wikipedia <ref>{{Cite pmid|32587963}}</ref> Single-cell transcriptomic analysis of SARS-CoV-2 reactive CD4 (+) T cells #MMPMID32587963 Meckiff BJ; Ramirez-Suastegui C; Fajardo V; Chee SJ; Kusnadi A; Simon H; Grifoni A; Pelosi E; Weiskopf D; Sette A; Ay F; Seumois G; Ottensmeier CH; Vijayanand P bioRxiv 2020[Jun]; ä (ä): ä PMID32587963show ga The contribution of CD4 (+) T cells to protective or pathogenic immune responses to SARS-CoV-2 infection remains unknown. Here, we present large-scale single-cell transcriptomic analysis of viral antigen-reactive CD4 (+) T cells from 32 COVID-19 patients. In patients with severe disease compared to mild disease, we found increased proportions of cytotoxic follicular helper (T (FH) ) cells and cytotoxic T helper cells (CD4-CTLs) responding to SARS-CoV-2, and reduced proportion of SARS-CoV-2 reactive regulatory T cells. Importantly, the CD4-CTLs were highly enriched for the expression of transcripts encoding chemokines that are involved in the recruitment of myeloid cells and dendritic cells to the sites of viral infection. Polyfunctional T helper (T (H) )1 cells and T (H) 17 cell subsets were underrepresented in the repertoire of SARS-CoV-2-reactive CD4 (+) T cells compared to influenza-reactive CD4 (+) T cells. Together, our analyses provide so far unprecedented insights into the gene expression patterns of SARS-CoV-2 reactive CD4 (+) T cells in distinct disease severities. äSingle-cell transcriptomic analysis of SARS-CoV-2 reactive CD4 (+) T c(epmc).pdf DeepDyve Pubget Overpricing