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10.1016/j.medcli.2020.05.012

http://scihub22266oqcxt.onion/10.1016/j.medcli.2020.05.012
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32586669!7269959!32586669
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suck abstract from ncbi

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  • Evaluation of organ function in patients with severe COVID-19 infections #MMPMID32586669
  • Zhu Y; Du Z; Zhu Y; Li W; Miao H; Li Z
  • Med Clin (Barc) 2020[Sep]; 155 (5): 191-196 PMID32586669show ga
  • OBJECTIVE: The purpose of our study was to assess organ function in 102 patients with severe COVID-19 infections, using retrospective clinical analysis. MATERIAL AND METHODS: A retrospective analysis was conducted on 102 patients with severe COVID-19 infections. The patients were divided into a survival group (n=73) and a non-survival group (n=29) according to their prognosis. The age, sex, underlying diseases, clinical laboratory data within 48h (routine blood tests, ALT, AST, TBIL, ALB, BUN, CR, D-Dimer, PT, APTT, FIB, F VIII:C, CK-MB, CK, and LDH), and ventilation status were collected. The organ functions of these severe COVID-19 patients were assessed by comparing the differences between the two groups. RESULTS: AST, BUN, CR, CK-MB, LDH, and CK in the non-survival group were higher than those in the survival group, and the differences were statistically significant (P<0.05). D-Dimer, PT, FIB, and F VIII:C in the non-survival group were higher than the values observed in the survival group, and the differences were statistically significant (P<0.05). PLT, AST, BUN, CR, D-Dimer, PT, FIB, F VIII:C, CK-MB, CK, and LDH predicted the area under the ROC curve (AUC) of the COVID19 endpoint events and were 0.721, 0.854, 0.867, 0.757, 0.699, 0.679, 0.715, 0.811, 0.935, and 0.802, respectively. CONCLUSION: The results showed that there were different degrees of damage to the liver, kidneys, blood coagulation, and heart function in the non-survival group. In addition, PLT, AST, BUN, CR, D-Dimer, PT, FIB, F VIII:C, CK-MB, CK, and LDH had value in evaluating disease prognosis.
  • |*Betacoronavirus[MESH]
  • |*Severity of Illness Index[MESH]
  • |Adult[MESH]
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |Biomarkers/blood[MESH]
  • |Case-Control Studies[MESH]
  • |China/epidemiology[MESH]
  • |Clinical Laboratory Techniques[MESH]
  • |Coronavirus Infections/blood/diagnosis/mortality/*physiopathology[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Multiple Organ Failure/blood/diagnosis/mortality/*virology[MESH]
  • |Organ Dysfunction Scores[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/blood/diagnosis/mortality/*physiopathology[MESH]
  • |Prognosis[MESH]
  • |ROC Curve[MESH]
  • |Retrospective Studies[MESH]


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  • suck abstract from ncbi

    191 5.155 2020