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10.1016/j.jcv.2020.104500

http://scihub22266oqcxt.onion/10.1016/j.jcv.2020.104500
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32585619!7278630!32585619
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suck abstract from ncbi


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pmid32585619      J+Clin+Virol 2020 ; 129 (ä): 104500
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  • Evaluation of rapid antigen test for detection of SARS-CoV-2 virus #MMPMID32585619
  • Mak GC; Cheng PK; Lau SS; Wong KK; Lau CS; Lam ET; Chan RC; Tsang DN
  • J Clin Virol 2020[Aug]; 129 (ä): 104500 PMID32585619show ga
  • BACKGROUND: The rapid diagnosis of Coronavirus Disease 2019 (COVID-19) patients is essential to reduce the disease spread. Rapid antigen detection (RAD) tests are available, however, there is scanty data on the performance of RAD tests. OBJECTIVE: To evaluate the performance of the commercially available BIOCREDIT COVID-19 Ag test and compare it with RT-PCR for detecting Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) virus. Analytical sensitivity for the detection of SARS-CoV-2 virus was determined for the RAD test using viral culture and RT-PCR as reference methods. The RAD test was further evaluated using respiratory samples collected from confirmed COVID-19 patients. The results were compared with RT-PCR test. RESULTS: The detection limits between RAD test, viral culture and RT-PCR varied hugely. RAD was 10(3) fold less sensitive than viral culture while RAD was 10(5) fold less sensitive than RT-PCR. The RAD test detected between 11.1 % and 45.7 % of RT-PCR-positive samples from COVID-19 patients. CONCLUSIONS: This study demonstrated that the RAD test serves only as adjunct to RT-PCR test because of potential for false-negative results.
  • |Antigens, Viral/*analysis[MESH]
  • |Betacoronavirus/*immunology[MESH]
  • |COVID-19[MESH]
  • |COVID-19 Testing[MESH]
  • |Clinical Laboratory Techniques/*methods[MESH]
  • |Coronavirus Infections/*diagnosis[MESH]
  • |Humans[MESH]
  • |Immunoassay/*methods[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*diagnosis[MESH]
  • |SARS-CoV-2[MESH]


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