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10.1016/j.clim.2020.108517 http://scihub22266oqcxt.onion/10.1016/j.clim.2020.108517 32585295!7308779!32585295     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Clin+Immunol 2020 ; 218 (ä): 108517 Nephropedia Template TP {{tp|p=32585295|t=2020. Inhibition of cytokine signaling by ruxolitinib and implications for COVID-19 treatment |pdf=|usr=}}{{32585295}} gab.com Text Inhibition of cytokine signaling by ruxolitinib and implications for COVID-19 treatment JO: Clin Immunol http://www.kidney.de/pget.php?&tw=1&pmid=32585295 #FOAvip Approximately 15% of patients with coronavirus disease 2019 (COVID-19) experience severe disease, and 5% progress to critical stage that can result in rapid death. No vaccines or antiviral treatments have yet proven effective against COVID-19. Patients with severe COVID-19 experience elevated plasma levels of pro-inflammatory cytokines, which can result in cytokine storm, followed by massive immune cell infiltration into the lungs leading to alveolar damage, decreased lung function, and rapid progression to death. As many of the elevated cytokines signal through Janus kinase (JAK)1/JAK2, inhibition of these pathways with ruxolitinib has the potential to mitigate the COVID-19-associated cytokine storm and reduce mortality. This is supported by preclinical and clinical data from other diseases with hyperinflammatory states, where ruxolitinib has been shown to reduce cytokine levels and improve outcomes. The urgent need for treatments for patients with severe disease support expedited investigation of ruxolitinib for patients with COVID-19. Twit Text FOAVip Inhibition of cytokine signaling by ruxolitinib and implications for COVID-19 treatment ????Clin Immunol http://www.kidney.de/pget.php?&tw=1&pmid=32585295 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32585295 #FOAvip English Wikipedia <ref>{{Cite pmid|32585295}}</ref> Inhibition of cytokine signaling by ruxolitinib and implications for COVID-19 treatment #MMPMID32585295 Yeleswaram S; Smith P; Burn T; Covington M; Juvekar A; Li Y; Squier P; Langmuir P Clin Immunol 2020[Sep]; 218 (ä): 108517 PMID32585295show ga Approximately 15% of patients with coronavirus disease 2019 (COVID-19) experience severe disease, and 5% progress to critical stage that can result in rapid death. No vaccines or antiviral treatments have yet proven effective against COVID-19. Patients with severe COVID-19 experience elevated plasma levels of pro-inflammatory cytokines, which can result in cytokine storm, followed by massive immune cell infiltration into the lungs leading to alveolar damage, decreased lung function, and rapid progression to death. As many of the elevated cytokines signal through Janus kinase (JAK)1/JAK2, inhibition of these pathways with ruxolitinib has the potential to mitigate the COVID-19-associated cytokine storm and reduce mortality. This is supported by preclinical and clinical data from other diseases with hyperinflammatory states, where ruxolitinib has been shown to reduce cytokine levels and improve outcomes. The urgent need for treatments for patients with severe disease support expedited investigation of ruxolitinib for patients with COVID-19. |Anti-Inflammatory Agents/pharmacokinetics/pharmacology[MESH] |Betacoronavirus/immunology/*pathogenicity[MESH] |COVID-19[MESH] |Coronavirus Infections/complications/*drug therapy/immunology/virology[MESH] |Cytokine Release Syndrome/complications/immunology/*prevention & control/virology[MESH] |Cytokines/*antagonists & inhibitors/genetics/immunology[MESH] |Drug Dosage Calculations[MESH] |Gene Expression Regulation[MESH] |Host-Pathogen Interactions/drug effects/immunology[MESH] |Humans[MESH] |Janus Kinase 1/antagonists & inhibitors/genetics/immunology[MESH] |Janus Kinase 2/antagonists & inhibitors/genetics/immunology[MESH] |Lung/drug effects/immunology/pathology/virology[MESH] |Nitriles[MESH] |Pandemics[MESH] |Pneumonia, Viral/complications/*drug therapy/immunology/virology[MESH] |Protein Kinase Inhibitors/pharmacokinetics/*pharmacology[MESH] |Pyrazoles/pharmacokinetics/*pharmacology[MESH] |Pyrimidines[MESH] |SARS-CoV-2[MESH] |Severe Acute Respiratory Syndrome/complications/immunology/*prevention & control/virology[MESH] |Severity of Illness Index[MESH]Inhibition of cytokine signaling by ruxolitinib and implications for C(epmc).pdf DeepDyve Pubget Overpricing