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10.1111/myc.13135

http://scihub22266oqcxt.onion/10.1111/myc.13135
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32585069!7361517!32585069
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suck abstract from ncbi


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pmid32585069      Mycoses 2020 ; 63 (8): 766-770
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  • COVID-19-associated pulmonary aspergillosis (CAPA) in patients admitted with severe COVID-19 pneumonia: An observational study from Pakistan #MMPMID32585069
  • Nasir N; Farooqi J; Mahmood SF; Jabeen K
  • Mycoses 2020[Aug]; 63 (8): 766-770 PMID32585069show ga
  • BACKGROUND: Invasive aspergillosis is a well-known complication of severe influenza pneumonia with acute respiratory distress syndrome (ARDS). However, recent studies are reporting emergence of aspergillosis in severe COVID-19 pneumonia, named as COVID-19-associated pulmonary aspergillosis (CAPA). METHODS: A retrospective observational study was conducted in patients with severe COVID-19 pneumonia from February 2020 to April 2020. Patients >/=18 years of age with clinical features and abnormal chest imaging with confirmed COVID-19 by RT-PCR for SARS-CoV-2 were included. CAPA was diagnosed based on clinical parameters, radiological findings and mycological data. Data were recorded on a structured proforma, and descriptive analysis was performed using Stata ver 12.1. RESULTS: A total of 147 patients with confirmed COVID-19 and 23 (15.6%) patients requiring ICU admission were identified. Aspergillus species were isolated from tracheal aspirates of nine (39.1%) patients, and of these, five patients (21.7%) were diagnosed with CAPA and four (17.4%) had Aspergillus colonisation. The mean age of patients with CAPA was 69 years (Median age: 71, IQR: 24, Range: 51-85), and 3/5 patients were male. The most frequent co-morbid was diabetes mellitus (4/5). The overall fatality rate of COVID-19 patients with aspergillosis was 44% (4/9). The cause of death was ARDS in all three patients with CAPA, and the median length of stay was 16 days (IQR: 10; Range 6-35 days). CONCLUSION: This study highlights the need for comparative studies to establish whether there is an association of aspergillosis and COVID-19 and the need for screening for fungal infections in severe COVID-19 patients with certain risk factors.
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |Azithromycin/therapeutic use[MESH]
  • |COVID-19[MESH]
  • |Coronavirus Infections/*complications/drug therapy[MESH]
  • |Diabetes Complications/complications[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Hydroxychloroquine/therapeutic use[MESH]
  • |Invasive Pulmonary Aspergillosis/*complications/drug therapy[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Nasopharynx/virology[MESH]
  • |Pakistan[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*complications/drug therapy[MESH]
  • |Respiratory Distress Syndrome/complications/mortality[MESH]
  • |Retrospective Studies[MESH]


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