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10.7554/eLife.56935 http://scihub22266oqcxt.onion/10.7554/eLife.56935 32584256!7316509!32584256     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32584256&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Elife 2020 ; 9 (ä): ä Nephropedia Template TP {{tp|p=32584256|t=2020. Specific labeling of synaptic schwann cells reveals unique cellular and molecular features |pdf=|usr=}}{{32584256}} gab.com Text Specific labeling of synaptic schwann cells reveals unique cellular and molecular features JO: Elife http://www.kidney.de/pget.php?&tw=1&pmid=32584256 #FOAvip Perisynaptic Schwann cells (PSCs) are specialized, non-myelinating, synaptic glia of the neuromuscular junction (NMJ), that participate in synapse development, function, maintenance, and repair. The study of PSCs has relied on an anatomy-based approach, as the identities of cell-specific PSC molecular markers have remained elusive. This limited approach has precluded our ability to isolate and genetically manipulate PSCs in a cell specific manner. We have identified neuron-glia antigen 2 (NG2) as a unique molecular marker of S100beta+ PSCs in skeletal muscle. NG2 is expressed in Schwann cells already associated with the NMJ, indicating that it is a marker of differentiated PSCs. Using a newly generated transgenic mouse in which PSCs are specifically labeled, we show that PSCs have a unique molecular signature that includes genes known to play critical roles in PSCs and synapses. These findings will serve as a springboard for revealing drivers of PSC differentiation and function. Twit Text FOAVip Specific labeling of synaptic schwann cells reveals unique cellular and molecular features ????Elife http://www.kidney.de/pget.php?&tw=1&pmid=32584256 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32584256 #FOAvip English Wikipedia <ref>{{Cite pmid|32584256}}</ref> Specific labeling of synaptic schwann cells reveals unique cellular and molecular features #MMPMID32584256 Castro R; Taetzsch T; Vaughan SK; Godbe K; Chappell J; Settlage RE; Valdez G Elife 2020[Jun]; 9 (ä): ä PMID32584256show ga Perisynaptic Schwann cells (PSCs) are specialized, non-myelinating, synaptic glia of the neuromuscular junction (NMJ), that participate in synapse development, function, maintenance, and repair. The study of PSCs has relied on an anatomy-based approach, as the identities of cell-specific PSC molecular markers have remained elusive. This limited approach has precluded our ability to isolate and genetically manipulate PSCs in a cell specific manner. We have identified neuron-glia antigen 2 (NG2) as a unique molecular marker of S100beta+ PSCs in skeletal muscle. NG2 is expressed in Schwann cells already associated with the NMJ, indicating that it is a marker of differentiated PSCs. Using a newly generated transgenic mouse in which PSCs are specifically labeled, we show that PSCs have a unique molecular signature that includes genes known to play critical roles in PSCs and synapses. These findings will serve as a springboard for revealing drivers of PSC differentiation and function. |Animals[MESH] |Antigens/*metabolism[MESH] |Biomarkers/metabolism[MESH] |Mice[MESH] |Mice, Transgenic[MESH] |Muscle, Skeletal/*metabolism[MESH] |Neuromuscular Junction/*physiology[MESH] |Proteoglycans/*metabolism[MESH]Specific labeling of synaptic schwann cells reveals unique cellular an(epmc).pdf DeepDyve Pubget Overpricing