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Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 J+Infect+Dis 2020 ; 222 (6): 894-898 Nephropedia Template TP
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Elevated Expression of Serum Endothelial Cell Adhesion Molecules in COVID-19 Patients #MMPMID32582936
Tong M; Jiang Y; Xia D; Xiong Y; Zheng Q; Chen F; Zou L; Xiao W; Zhu Y
J Infect Dis 2020[Aug]; 222 (6): 894-898 PMID32582936show ga
In a retrospective study of 39 COVID-19 patients and 32 control participants in China, we collected clinical data and examined the expression of endothelial cell adhesion molecules by enzyme-linked immunosorbent assays. Serum levels of fractalkine, vascular cell adhesion molecule-1 (VCAM-1), intercellular adhesion molecule 1 (ICAM-1), and vascular adhesion protein-1 (VAP-1) were elevated in patients with mild disease, dramatically elevated in severe cases, and decreased in the convalescence phase. We conclude the increased expression of endothelial cell adhesion molecules is related to COVID-19 disease severity and may contribute to coagulation dysfunction.