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10.3389/fmolb.2020.00120

http://scihub22266oqcxt.onion/10.3389/fmolb.2020.00120
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32582766!7292051!32582766
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suck abstract from ncbi


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pmid32582766      Front+Mol+Biosci 2020 ; 7 (ä): 120
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  • Does Early Childhood Vaccination Protect Against COVID-19? #MMPMID32582766
  • Sidiq KR; Sabir DK; Ali SM; Kodzius R
  • Front Mol Biosci 2020[]; 7 (ä): 120 PMID32582766show ga
  • The coronavirus disease 2019 (COVID-19) is an on-going pandemic caused by the SARS-coronavirus-2 (SARS-CoV-2) which targets the respiratory system of humans. The published data show that children, unlike adults, are less susceptible to contracting the disease. This article aims at understanding why children constitute a minor group among hospitalized COVID-19 patients. Here, we hypothesize that the measles, mumps, and rubella (MMR) vaccine could provide a broad neutralizing antibody against numbers of diseases, including COVID-19. Our hypothesis is based on the 30 amino acid sequence homology between the SARS-CoV-2 Spike (S) glycoprotein (PDB: 6VSB) of both the measles virus fusion (F1) glycoprotein (PDB: 5YXW_B) and the rubella virus envelope (E1) glycoprotein (PDB: 4ADG_A). Computational analysis of the homologous region detected the sequence as antigenic epitopes in both measles and rubella. Therefore, we believe that humoral immunity, created through the MMR vaccination, provides children with advantageous protection against COVID-19 as well, however, an experimental analysis is required.
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