Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.3389/fimmu.2020.01312 http://scihub22266oqcxt.onion/10.3389/fimmu.2020.01312 32582222!7291598!32582222     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Immunol 2020 ; 11 (ä): 1312 Nephropedia Template TP {{tp|p=32582222|t=2020. The Lung Macrophage in SARS-CoV-2 Infection: A Friend or a Foe?|pdf=|usr=}}{{32582222}} gab.com Text The Lung Macrophage in SARS-CoV-2 Infection: A Friend or a Foe JO: Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=32582222 #FOAvip Respiratory, circulatory, and renal failure are among the gravest features of COVID-19 and are associated with a very high mortality rate. A common denominator of all affected organs is the expression of angiotensin-converting enzyme 2 (ACE2), a protease responsible for the conversion of Angiotensin 1-8 (Ang II) to Angiotensin 1-7 (Ang 1-7). Ang 1-7 acts on these tissues and in other target organs via Mas receptor (MasR), where it exerts beneficial effects, including vasodilation and suppression of inflammation and fibrosis, along an attenuation of cardiac and vascular remodeling. Unfortunately, ACE2 also serves as the binding receptor of SARS viral spike glycoprotein, enabling its attachment to host cells, with subsequent viral internalization and replication. Although numerous reports have linked the devastating organ injuries to viral homing and attachment to organ-specific cells widely expressing ACE2, little attention has been given to ACE-2 expressed by the immune system. Herein we outline potential adverse effects of SARS-CoV2 on macrophages and dendritic cells, key cells of the immune system expressing ACE2. Specifically, we propose a new hypothesis that, while macrophages play an important role in antiviral defense mechanisms, in the case of SARS-CoV, they may also serve as a Trojan horse, enabling viral anchoring specifically within the pulmonary parenchyma. It is tempting to assume that diverse expression of ACE2 in macrophages among individuals might govern the severity of SARS-CoV-2 infection. Moreover, reallocation of viral-containing macrophages migrating out of the lung to other tissues is theoretically plausible in the context of viral spread with the involvement of other organs. Twit Text FOAVip The Lung Macrophage in SARS-CoV-2 Infection: A Friend or a Foe ????Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=32582222 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32582222 #FOAvip English Wikipedia <ref>{{Cite pmid|32582222}}</ref> The Lung Macrophage in SARS-CoV-2 Infection: A Friend or a Foe? #MMPMID32582222 Abassi Z; Knaney Y; Karram T; Heyman SN Front Immunol 2020[]; 11 (ä): 1312 PMID32582222show ga Respiratory, circulatory, and renal failure are among the gravest features of COVID-19 and are associated with a very high mortality rate. A common denominator of all affected organs is the expression of angiotensin-converting enzyme 2 (ACE2), a protease responsible for the conversion of Angiotensin 1-8 (Ang II) to Angiotensin 1-7 (Ang 1-7). Ang 1-7 acts on these tissues and in other target organs via Mas receptor (MasR), where it exerts beneficial effects, including vasodilation and suppression of inflammation and fibrosis, along an attenuation of cardiac and vascular remodeling. Unfortunately, ACE2 also serves as the binding receptor of SARS viral spike glycoprotein, enabling its attachment to host cells, with subsequent viral internalization and replication. Although numerous reports have linked the devastating organ injuries to viral homing and attachment to organ-specific cells widely expressing ACE2, little attention has been given to ACE-2 expressed by the immune system. Herein we outline potential adverse effects of SARS-CoV2 on macrophages and dendritic cells, key cells of the immune system expressing ACE2. Specifically, we propose a new hypothesis that, while macrophages play an important role in antiviral defense mechanisms, in the case of SARS-CoV, they may also serve as a Trojan horse, enabling viral anchoring specifically within the pulmonary parenchyma. It is tempting to assume that diverse expression of ACE2 in macrophages among individuals might govern the severity of SARS-CoV-2 infection. Moreover, reallocation of viral-containing macrophages migrating out of the lung to other tissues is theoretically plausible in the context of viral spread with the involvement of other organs. |Angiotensin-Converting Enzyme 2[MESH] |Betacoronavirus/immunology/*metabolism[MESH] |COVID-19[MESH] |Coronavirus Infections/immunology/pathology[MESH] |Dendritic Cells/immunology/*metabolism/virology[MESH] |Humans[MESH] |Lung/*pathology/virology[MESH] |Macrophages, Alveolar/immunology/*metabolism/virology[MESH] |Pandemics[MESH] |Parenchymal Tissue/pathology/virology[MESH] |Peptidyl-Dipeptidase A/*metabolism[MESH] |Pneumonia, Viral/immunology/pathology[MESH] |Proto-Oncogene Mas[MESH] |Receptors, Virus/metabolism[MESH] |SARS-CoV-2[MESH]The Lung Macrophage in SARS-CoV-2 Infection: A Friend or a Foe?(epmc).pdf DeepDyve Pubget Overpricing